복막투석 환자에서 혈청 N-terminal pro-Brain Natriuretic Peptide와 세포외액과 좌심실부전간의 연관관계에 관한 연구

Abstract

Background This study inquired the relationship between serum N-terminal pro-brain natriuretic peptide(NT-pro BNP) levels and extracellular water(ECW%) and left ventricular(LV) dysfunction in continuous ambulatory peritoneal dialysis (CAPD) patients. Method We conducted a prospective study of 30 CAPD patients : 19 males, 11 females: mean age 47±12 years; 14 with diabetes mellitus and 16 non-diabetes mellitus. Each patient was admitted to Department of internal medicine, Chosun University Hospital between Febrary, 2006 and Octorber, 2006. Echocardiography was performed using a HDI 5000(Philips,USA), allowing M-mode,two-dimensional measurement. A multifrequency bioimpedance analyzer was used; ECW% was calculated as a percentage of total body water and was understood the index of volume load of CAPD patients. Result Mean serum NT-pro BNP level was 14236.56(83-35000)pg/mL.. LV mass index and LV ejection fraction (%) were 151.67±42.5g/m², 57.48±12.9%. Mean Extracellular water(%) was 35.97±1.04%. Serum NT-pro BNP levels correlated positively with LV mass index (r=0.768, p=0.01), and Extracellular water (%)(r=0.866, p=0.01) and negatively with LV ejection fraction (r=-0.808, p=0.01.) Conclusion Serum NT-pro BNP levels significantly correlated with LV mass index,LV ejection fraction and extracellular water(%). Therefore, serum NT-pro BNP levels can be clinical predictive maker for LV hypertrophy, LV dysfunction and hydration status in CAPD patients.