백서에서 초기 골 형성에 미치는 키토산과 치아회분말의 효과

Abstract

Purpose : The purpose of this study was to evaluate the healing effect of grafting materials after implantation of chitosan and tooth-ash mixture. Material and Method : The critical size defect of rat calvarium, 8mm size in diameter, was used and 75 rats were divided into 5 experimental groups. The control group was performed only artificial bone defect in the frontal area of rat and experimental group was divided 4 parts. The experimental group 1 was grafted with tooth-ash, the experimental group 2 was grafted with pig tooth-ash and plaster of Paris mixture, experimental group 3 was grafted with pig tooth-ash and chitosan combination, experimental group 4 was grafted with chitosan only. The experimental rats were sacrificed at the 2nd , 4th and 8th weeks after operation. Result : The results were as follows ; More significant new bone forming activity was found in all experimental group than control group. In all groups, there were more significant new bone forming activity was found in 8 weeks group than 4 weeks group. There were slightly more new bone forming activity in group 3. Conclusion : These results suggested that the mixture of chitosan and tooth-ash might be effective materials for new bone formation in osseous defects.