대장의 샘암종에서 paxillin과 galectin-3 발현

Abstract

Background: The focal adhesion complex including paxillin is an important link between the actin cytoskeleton and the plasma membrane and proteins that assemble at sites of attachment of the cell to the extracellular matrix. Galectin-3 is a β-galactoside binding protein and expressed at elevated levels in a variety of neoplastic cells. The aim of this study was to investigate, by clinicopathologic and survival analysis, the correlation between the tumor progression and prognosis and the expression of paxillin and galectin-3 in colorectal cancer. Methods: Expression of paxillin and galectin-3 was evaluated using immunohistochemistry in 125 patients with colorectal adenocarcinoma. The results were compared with both clinicopathological factors (sex, location, histologic grade, tumor size, tumor depth, lymph node metastasis, distant metastasis and stage) and the overall survival. Results: The paxillin expression was positive in 67 cases (53.6%) and significantly correlated with a smaller tumor size (p=0.001), shallower tumor depth (p=0.007) and lower stage (p=0.03). The galectin-3 expression was positive in 82 cases (65.6%) and significantly correlated with deeper invasion to wall (p=0.000), lymph node metastasis (p=0.000), higher stage (p=0.000). In a univariate survival analysis, lymph node metastasis (p=0.001), distant metastasis (p=0.000), stage (p=0.000) and galectin-3 expression (p=0.04) were independent predictors of patient outcome. Conclusion: These findings suggest that the decreased paxillin expression and increased galectin-3 expression may play a role in the tumor invasion and progression. P axillin expression may be associated with good prognostic marker. Galectin-3 expression may be associated with poor prognosis and is an useful factor for predicting prognosis of patients with colorectal adenocarcinoma.