국산 흡수성 차단막의 개발을 위한 실험적 연구

Abstract

The purpose of this study was comparing the effect of 4 newly designed bioresorbable membranes on bone regeneration in rat cranial defects. Standardized artificial bony defects were prepared at 30 rat craniums, and covered with polydioxanone(PDS), PDS/F-127, polylactide glycolic acid(PLGA), and PLGA/F-127 membranes, respectively. So The animals were classified 5 groups; group 1 - no membrane (6 rats), group 2 - PDS (6), group 3 - PDS/F-127 (6), group 4 - PLGA (6), and group 5 - PLGA/F-127 (6). These animals were sacrificed at 4 and 8 weeks and the operation to make specimens was done and the specimens were observed with light microscopy. The comparative effects in the bone regeneration of each groups were evaluated and the remaining rate of each membranes were analysed. The new bone formation was greater in PLGA and PLGA/F-127 membrane groups than PDS or PDS/F-127 groups. And the former groups were resorbed more lately than the latter. PLGA/F127 was good to manipulate because of its hydrophillic property, but resorbed more rapidly than PLGA. So, the amount of new bone formation in groups using PLGA/F127 was less than in groups using PLGA. In conclussion, PLGA was the best membranes among the membranes used in this study.