Propofol이 백서 자궁 평활근의 수축에 미치는 영향

Abstract

Background : Propofol is an alternative to thiopenthal as an intravenous induction agent for cesarean section. It is also used as a sedative agent for supplementation of regional blockade during cesarean section. It has been reported that propofol relaxes not only vascular smooth muscle but also other smooth muscle. The aim of the present study was to investigate the effect of propofol on rat uterine smooth muscle in an isolated preparation. Methods : Uterine smooth muscle tissues were obtained from rats(n=21). The muscle strips were suspended in tissue baths and isometric tension was recorded. After spontaneous or oxytocin induced activity had been accomplished in the buffer solution as a control, propofol (0.5 to 20 μg/ml) in fat emulsion was applied cumulatively to the bath and the effects were continuously recorded. Results : In vitro propofol induced a dose-dependent inhibition of spontaneous as well as oxytocin induced myometrial contractile activity. Propofol concentrations of 1 and 2 μg/ml had no significant effect on the active tension developed by muscle contraction. However, Complete muscular relaxations on spontaneous and oxytocin-induced contractility were obtained at a concentration of 10 μg/ml and 20 μg/ml. Conclusions : Propofol inhibited spontaneous and oxytocin-induced uterine smooth muscle contractions.