영아기 호흡기 질환의 이환율에 관한 연구

Abstract

Purpose : Respiratory tract infections are common in the first year of life. Severity of respiratory tract infection in infants is associated with early-life environmental factors. In recent, genetic studies suggest a role of heredity in susceptibility to severe respiratory tract infection(RTI) in infants. We designed a case control study to further investigate relative importance of familial influence in risk of respiratory tract infection in infants compared to environmental factors. Methods : We selected 126 children(44 cases; 82 controls) that admitted or visited to Chosun University Hospital. Cases were infants under age 1 year admitted to hospital with severe respiratory tract infection. Familial history and other factors were recorded in cases and controls by questionnaire. Results : Out of 126 infants, patients admitted with severe respiratory tract infection are 44 cases. Diagnosis of patients with RTI are aucte bronchitis 15cases(34.1%), pneumonia12cases(27.3%), acute nasopharyngitis 7cases(15.9%), acute bronchiolitis 5cases(11.4%), infantile asthma 3cases(6.8%), and croup 2cases(4.5%). The crude odd ratio of repiratory tract infection of parental smoking is 3.35 and cow mik feeding 3.13, prematurity ＆ low birth weight 2.39, maternal allergic disease 2.13, and child allergy 1.92. Conclusion : Maternal allergic disease, parental smoking, prematurity and low birth weight, and Allergic diseases increased the risk of respiratory tract infection in infants. Breast milk feeding decreased that. These results support the possibility that genetic factors play an important role in susceptibility to recurrent and severe respiratory infections in early life.