약물 중독 환자에서 아트로핀 사용후 나타나는 정신증에 대한 연구

Abstract

Purpose: The objectives of this study are to investigated the clinical characteristics of atropine induced psychosis in patients with drug intoxication required atropine administration and to assess relationship of influencing factors of atropine induced psychosis. Methods: This study is reviewed retrospectively the medical records of patients with drug intoxication required atropine administration in Chosun University Hospital emergency center from January 2001 to December 2004. This is compared to vital sign, arterial blood gas analysis(ABGA), amount and kinds of ingestions, underlying disease, transfer, administered amount and velocity of atropine in patients of drug intoxication after administration of atropine. And then time of revealed symptom, duration of recovery and administered amount and velocity of atropine in patients with atropine induced psychosis are investigated. Results: Fifty patients are investigated. Twenty patients are revealed atropine induced psychosis. In these paitents, organophosphate insecticide intoxication are twenty, and carbamate intoxication are five and others are three. In patients with atropine induced psychosis, average duration of revealed symptom is 41.7hr. and average amount of administered atropine is 163.65mg. Atropine induced psychosis influence treatment because amount and duration of atropine administraiton are reduced in these patients. The influencing factors of atropine induced psychosis are sexuality and pCO2. Conclusion: Atropine induced psychosis is high morbidity in patients with drug intoxication after atropine administration. The influencing factors of atropine induced psychosis are sexuality and pCO2. The results suggest that influencing factor of atropine induced psychosis may be helpful in the treatment of patient with drug intoxication.