소아 비만에서 Leptin, Adiponectin 및 Leptin/Adiponectin Ratio와 대사 장애의 연관성에 관한 연구
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- Issued Date
- 2006
- Abstract
- Purpose : There are some kinds of adipocytokine which has been reported to be secreted from adipocytes : leptin, IL-6, TNF-α, PAI-1, and adiponectin. Abnormality in the secretion of the adipocytokine is involved in the development of metabolic disorders in the obesity. The aim of this study was to investigate the correlation of the serum leptin, adiponectin, and leptin/adiponectin ratio with metabolic disorders in the childhood obesity.
Methods : A total of 50 children (25 obese and 25 non-obese) were recruited in the pediatric outclinic of Chosun University Hospital from January 1st to June 30th 2005. Adiponectin, leptin, anthropometric parameters, fasting glucose, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglyceride, and fasting insulin levels were measured. The correlations of leptin and adiponectin levels with anthropometric parameters, glucose, insulin and lipids were analyzed by Pearson's correlation coefficients.
Results : All anthropometric data (BMI, midarm circumference, triceps and subscapular skinfold thickness, and percentage of body fat) of the obese group were higher than those of the non-obese group(P<0.001). The insulin and leptin levels of the obese group were significantly higher than those of the non-obese group(P<0.05, P<0.001 respectively). The HDL-cholesterol and adip- onectin levels of the obese group were significantly lower than those of the non-obese group(P<0.005, P<0.05 respectively). In the obese group, the leptin level was positively correlated with BMI and the percentage of body fat, but negatively correlated with adiponectin level. Moreover, the adiponectin level of the obese group was negatively correlated with BMI and the percentage of body fat, but positively correlated with leptin level. In the non-obese group, only insulin level was positively correlated with adiponectin. In the obese group, the leptin/adiponectin ratio was positively correlated with the percentage of body fat and leptin level. Also, the leptin/adiponectin ratio was positively correlated with BMI and the percentage of body fat in the non-obese group.
Conclusion : Leptin and adiponectin did not appear to have a major role linking various metabolic disorders in the childhood obesity, even though they were strongly associated with obesity indices. But, leptin/adiponectin ratio is suggested to be a predictor for the development of complications of obesity even in non-obese children.
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