세균성 피부 질환에서 황색 포도구균의 항생제 감수성에 관한 연구

Abstract

Background: Methicillin-resistant Staphylococcus aureus(MRSA) is an important nosocomial pathogen. It can also cause community-acquired infection. However there are few reports about MRSA in community-acquired infection. Objective: To evaluate the prevalence and antibiotic susceptibilities of Staphylococcus aureus(S. aureus) in community-acquired bacterial skin infections. Methods: Bacterial cultures and antimicrobial susceptibility tests were performed in outpatietns with bacterial skin infection from January 2004 to October 2005. Results: Of 252 pyoderma cases, bacteria were cultured from 145(57.5%) cases. Among them, S. aureus was isolated from 85(33.7%) patients. Eight(9.4%) S. aureus isolates were MRSA. The resistant rates of S. aureus against antibiotics were as follows: penicilin(PC) 97.6%, tetracyclin(TC) 29.7%, gentamycin(GM) 23.5%, tobramycin(TM) 16.2%, fusidic acid(FA) 13.5%, oxacillin(OX) 9.4%, erythromycin(EM) 8.1%, aberkacin(ABK) 5%, ciprofloxacin(CIP) 4.7%, rifampin(RIF) 2.7%, clindamycin(CM) 2.4%, trimethoprim/sulfamethoxazole(SXT) 2.4%, amoxicillin/clavulanic acid(AMC) 0%, teicoplanin(TEC) 0%, vanco- mycin(VA) 0%. The effective antibiotics in the treatment of MRSA were AMC(0%), TEC(0%) and VA(0%) Conclusion: S. aureus is was the most prominent pathogen in community-acquired pyoderma and it was sensitive to OX, EM, ABK, CIP, RIF, CM, SXT, AMC, TEC and VA. Among them, AMC, TEC and VA were also effective in treatment of MRSA.