사람 치은염 병소의 치면세균막에서 분리·동정된 Fusobacterium nucleatum의 수종 항생제에 대한 내성 검사

Abstract

Objectives: The purpose of this study was to investigate the antimicrobial susceptibility of Fusobacterium nucleatum isolated from the dental plaques in gingivitis lesion of Koreans. Methods: The minimal inhibitory concentration of 7 antibiotics for 34 strains of F. nucleatum was tested by broth microdilution assay. Results: The data showed that only 2 out of 34 strains have resistance to penicillin G, amoxicillin, and Augmentin (amoxicillin + clavulanic acid, 5:1). The other strains were sensitive to all of the antibiotics tested in this study except ciprofloxacin. Conclusion: These results suggest that penicillin G or amoxicillin could be used in the first choice antibiotics for the target of F. nucleatum in Koreans.