백서 모델로 유발한 폐색성 심근경색에서의 심관류 영상에 대한 연구

Abstract

Purpose : To test whether cardiac CT perfusion imaging can accurately delineate irreversibly damaged myocardium in occlusive myocardial infarction. Materials and Methods : Author used 8 rats with thoracotomy and ligation of left anterior descending coronary artery distal to its first diagonal artery. Also, performed a series of enhanced CT in rats that undergo after 30 minutes of occlusion and follow-up scan was done after 5 minutes. 3 rats were reexamined in one week later. After CT scanning, Rats were sacrified and occlusive myocardial infarcted hearts were extirpated for 2,3,5-triphenyltetrazolium chloride(TTC) histochemical staining. Stained slices were compared with CT images. The CT numbers(HU) of the infarct and non-infarct area on CT scan were estimated as contrast ratio(Contrast Ratio, CR= (Infarction HU/Ventricle HU)/(Non-infarction HU/Ventricle HU)) Results : The CT numbers(HU) in the infarct area was significant lower than that in normal myocardium. Quantitative analysis of CT attenuation showed significant difference in the CR and CT attenuation of infarct and reference areas(p＜0.05). The perfusion defects seen at perfusion CT scan showed slightly larger area than unstained areas at TTC staining. However, the sizes of the perfusion defects at perfusion CT correlated well with the sizes of unstained areas at TTC staining(p＜0.05). Conclusion : In a rat model, we could conclude that occlusive myocardial infarction might be accurately detected on CT perfusion scan. The perfusion defected area on CT represents the infarct area, irreversible myocardial damage.