Nitroglycerin이 백서 자궁 평활근의 수축에 미치는 영향

Abstract

Background It has been reported that nitroglycerin relaxes not only vascular smooth muscle but also uterine smooth muscle. The aim of the present study was to investigate the effect of nitroglycerin on rat uterine contractile activity in vitro. The effects of nitroglycerin on myometrial spontaneous activity and oxytocin-induced contractions were also observed. Methods Uterine smooth muscle tissues were obtained from non-pregnant female rats(n=21). The uterine segments were mounted in tissue baths. After spontaneous or oxytocin-induced activity had been accomplished, nitroglycerin in various concentrations was added to the bath and the effects were continuously registered. Results Nitroglycerin induced a dose-dependent inhibition of oxytocin-induced as well as spontaneous myometrial contractile activity. Complete muscular relaxation on spontaneous contractility was obtained at a concentration of 50 μg/ml. Complete muscular relaxation on oxytocin-induced contractility was obtained at a concentration of 75 μg/ml. Conclusion Nitroglycerin inhibited the uterine contractile response to exogenous oxytocin as well as spontaneous in the estrous rat.