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간성혼수 증상을 보이는 간질환 환자들에 있어서 분지사슬 아미노산의 투여 효과

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Author(s)
박호영
Issued Date
2021
Keyword
Adult BCAA (branched chain amino acid) Hepatic encephalopathy Lactulose Rifaximin
Abstract
Background : The therapeutic efficacy of BCAA in liver disease patients with hepatic encephalopathy is still controversial. Therefore, this study aimed to evaluate the effect of BCAA in patients with hepatic encephalopathy on hospitalized patients in Korea.
Method : We retrospectively reviewed a total of 72 cases based on electronic medical records in a tertiary hospital from January 1, 2010, to December 31, 2019. Those patients were classified into three groups; lactulose only group, lactulose with intravenous BCAA administration group, and lactulose with oral rifaximin administration group. Then we evaluated the clinical parameters such as elapsed time from the administration of these medications to the recovery of consciousness, changes of albumin levels as well as child-pugh score before and after the treatment, and hospitalization periods.
Results : Among the 72 cases, 41 cases were assigned to the lactulose only group, 6 cases to the lactulose with intravenous BCAA administration group, and 25 cases to the lactulose with oral rifaximin administration group. Patients of the lactulose with intravenous BCAA group recovered their consciousness significantly faster than those of the lactulose only group (p<0.01). However, there was no statistically significant difference in albumin levels, Child-Pugh score, and hospitalization periods among those groups.
Conclusion : We suggest that the co-administration of lactulose and intravenous BCAA is beneficial in liver disease patients with hepatic encephalopathy.
Alternative Title
Effect of BCAA(Branched Chain Amino Acid) in liver disease patients with hepatic encephalopathy
Alternative Author(s)
Park Ho Yeong
Affiliation
임상약학대학원 임상약학과
Department
임상약학대학원 임상약학과
Advisor
지준필, 방준석
Awarded Date
2021. 2
Table Of Contents
Ⅰ. 서론 1
A. 연구 배경 및 목적 1

Ⅱ. 연구 방법 4
A. 연구 대상 및 기간 4
B. 연구 방법 4
C. 분석 방법 5

Ⅲ. 연구 결과 6
A. 대상 환자의 분석 6
B. 약제 투여에 따른 간성혼수 치료 효과 비교 9
1. 혈중 알부민 변화 9
2. 재원 일수 10
3. Child-pugh score 변화 11
4. 의식 회복 시 까지 소요시간 12
5. 의식 회복 시 까지 소요시간 추가 분석 13

Ⅳ. 고찰 14

Ⅴ. 결론 16

Ⅵ. 참고문헌 17
Degree
Master
Publisher
조선대학교 임상약학대학원
Citation
[1]박호영, “간성혼수 증상을 보이는 간질환 환자들에 있어서 분지사슬 아미노산의 투여 효과,” 조선대학교 임상약학대학원, 2021.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/19245
http://chosun.dcollection.net/common/orgView/200000359548
Appears in Collections:
Medicine & Parmacy > Theses(Ph.D)(의학전문대학원/보건대학원/임상약학대학원)
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