한국 성인의 항산화 식품 섭취에 따른 인체 내 항산화능 변화를 예측하는 비파괴적 공명 라만분광법

Abstract

Aging is a phenomenon caused by a decrease in antioxidant activity, and skin carotenoid could be an appropriate indicator of human antioxidant level. Although many studies have found a strong correlation between serum carotenoids and skin carotenoids measured by resonance Raman spectoscopy (RRS), some information about Korean adult has not been reported yet. To determine if skin carotenoids score (SCS) measured by RRS could be used as a valid marker of antioxidant level among 42 participants, healthy adults aged 20 to 55 were administerd two antioxidant foods (commercial Tablet and wheat sprout powder). RRS equipment (BioPhotonic Scanner, Pharmanex, USA) was used for detecting the skin carotenoid level of the subjects. Daily adminstration of commercial Tablet, wheat sprout powder, and placebo was done for 4 weeks. The measurement of SCS assessed 3 times in each measurement during the period. The results of SCS from 0 day, at least 7 days apart, were statistically analyzed and compared to each group. We cannot find any correlation among three groups. In Tablet group, however, there was correlation with intake time; SCS before intake and SCS at 4 weeks after intake (p<0.05). In antioxidant activity of foods, IC50 of the Tablet is 3 times lower than that of wheat sprout. Commercial Tablet is better than wheat sprout in terms of increase of the SCS and antioxidant level in skin. This result might came from the effect of multiple antioxidant compounds, vitamins, and minerals contained in Tablet. In summary, RRS can determine the in vivo carotenoids concentration and antioxidant level in skin of Korean adult.