Comparison of the remineralization effect of newly-developed fluoride agents according to the depth of early carious lesions

Abstract

This study aimed to compare the re-mineralization effects of the new fluorine formulations of the 5% sodium fluoride adhesive film (NaF AF) and 38% silver diamine fluoride (SDF) with conventional 5% sodium fluoride varnish (NaF V), and whether the re-mineralization effect of each fluoride formulation is affected by the depth of the initial enamel caries. The re-mineralization effect of the SDF group was significantly greater than those of the NaF V and NaF AF groups (p<0.05). The NaF V and NaF AF groups showed a significantly greater re-mineralization effect than did the control group (artificial saliva) (p<0.05), and there was no difference between those two groups. Also, in the NaF V and NaF AF groups, there was no significant difference in the degree of re-mineralization depending on the depth of the initial enamel caries, but in the SDF group, a significantly greater amount of re-mineralization was observed in deep lesions than in shallow lesions (p<0.05). SDF is expected to expand the range of fluoride for the prevention and treatment of dental caries that were limited to initially shallow caries.