Most periapical lesions can be classified as apical periodontitis, radicular cyst, or abscess. Treatment options for large periapical lesions management range from conventional endodontic treatment to surgical treatment and extraction. Recently, the surgical treatment is only administered if the conventional endodontic therapy fails to restore the integrity of the peripheral tissue. This case report submits the successful treatment of a large periapical lesion using non-surgical endodontic therapy.