Assessment of clinical and radiographic outcomes of guided bone regeneration with dehydrothermally cross-linked collagen membrane around peri-implant dehiscence defects: Results from a 3-year randomized clinical trial

Abstract

The objective of this study was to determine the clinical and radiographic efficacy of dehydrothermally (DHT) cross-linked collagen membrane in the treatment of peri-implant dehiscence defects through a 3-year randomized clinical trial. This study involved a total of 30 patients in the preliminary study, but only 19 patients (experimental group [DHT cross-linked collagen membrane, n=6] and control group [non-cross-linked collagen membrane, n=13]) were followed-up for 3 years after setting the baseline immediately after final prosthesis. The mean and standard deviation of each clinical measurement (probing pocket depth and width of attached gingiva) and radiological measurement (marginal bone level and clinical crown-to-implant [C/I] ratio) indices were determined and compared using the nonparametric Mann-Whitney test at the 95% confidence level. No significant complications, such as surgical site exposure and or severe infection, was observed during the follow-up period. Marginal bone loss in the experimental group and control group were 0.14±0.40 mm and 0.08±0.30 mm (p=0.631) respectively. The clinical C/I ratio change in the experimental group and control group were 0.25±0.29 mm and 0.12±0.23 mm (p=0.557) respectively. The width of attached gingiva in the experimental group and control group were 2.27±2.49 mm and 2.58±1.18 mm (p=0.732) respectively. The differences were not statistically significant. These results suggest that the experimental group and control group had similar clinical outcome, and highlight the potential of DHT crosslinked collagen membrane for guided bone regeneration around peri-implant dehiscence defects.