Revisiting ameloblastoma through molecular and developmental biology aspects

Abstract

Ameloblastoma, is the most common, aggressive, and clinically significant odontogenic tumour, which is known to arise from odontogenic enamel epithelium and ectomesenchyme. Currently, there are no appropriate treatment methods and drugs except for surgical operation for treating ameloblastoma. In this manuscript, we revisit the concept of ameloblastoma through molecular and developmental biology to suggest new conceptual approaches based on the principal pathological elucidation with drug repositioning and phytochemistry. Overall, to understand and treat ameloblastoma, it is necessary that experimental model systems for precise functional evaluation of drugs and compounds with molecular and developmental biology approaches should be established.