성인남성의 지방간 개선을 위한 밀크씨슬 복용과 유산소운동이 간 기능 및 스트레스 효소에 미치는 영향

Abstract

Effects of taking milk thistle and aerobic exercise to improve fatty liver in adult men on liver function and stress enzymes Cho, Woo-Jin Advisor : Prof. Seo, Young-Hwan Ph. D. Department of Physical Education, Graduate School of Public Health, Chosun University In Korea, liver disease is a disease with a high mortality rate, the prevalence of liver disease is higher in men than in women, and decline in liver function is closely related to physical fatigue, and fatigue is directly related to stress. To improve liver disease caused by fatty liver, it would be an effective way to reduce fat through aerobic exercise and receive the help of health functional foods for liver protection and regeneration. This study was aimed at determining how milk thistle intake as a nutritional supplement during aerobic exercise affects liver function and stress enzymes in adult men with reduced liver function due to fatty liver disease. This is a study to use as basic data for healthy lifestyle guidelines for the treatment and prevention of liver disease in men, which is relatively high. The subjects who participated in the study were adult men aged 30 to 49 years old, with the relative criteria of one or more of AST and ALT exceeding 40 IU/L in the preliminary liver function enzyme test, and the absolute criteria of α-amylase exceeding 30 kIU/L in the stress enzyme test. 22 people who met all of the following were selected. All subjects were randomly assigned to 11 people each into IAG (Intake & Aerobic Group), a group that combined milk thistle intake and aerobic exercise, and NAG (Non intake & Aerobic Group), a group that performed only aerobic exercise without milk thistle intake. The study period is a total of 8 weeks. IAG was required to consume milk thistle from a health functional product provided by the researcher every morning after waking up and notify the researcher of the intake. NAG recommended avoiding the consumption of other health functional products, including milk thistle, for 8 weeks. The aerobic exercise program for both groups was identical, and aerobic exercise was performed three times a week. The exercise intensity is at least moderate intensity of 60-75% of HRmax, and the exercise quarters are 1-2 weeks (1st quarter), 3-4 weeks (2nd quarter), 5-6 weeks (3rd quarter), and 7-8 weeks (4th quarter). ), one exercise time was 60 minutes, consisting of 5 minutes of warm-up, 50 minutes of main exercise, and 5 minutes of cool-down. All results of this study were presented as mean ± standard deviation, and data processing was performed using paired samples t-test and two methods to determine pre- and post-changes in each group through the statistical program SPSS 24.0 ver. In order to determine differences between groups during different periods, independent samples t-test was performed based on the statistical significance level of ɑ=.05. Results A. Changes in liver function enzymes The liver function enzyme AST decreased post-test compared to pre-test in both IAG (p<.001***) and NAG (p<.01**) groups, showing a significant level of change and ALT also decreased post-test compared to pre-test in both IAG (p<.001***) and NAG (p<.01**) groups, showing a significant level of change. B. Changes in stress enzymes The stress enzyme α-amylase decreased post-test compared to pre-test in both IAG (p<.001***) and NAG (p<.01**) groups, showing a significant level of change. C. Differences in liver function enzymes The difference in the liver function enzyme AST was found to be homogeneous as there was no significant difference in the pretest between the two groups (p>.05), and a significant difference was found in the posttest to establish heterogeneity (p<.001***). As for the difference in ALT, no significant difference was found between the two groups in the pretest, so homogeneity was found to be established (p>.05), and a significant difference was found in the posttest, indicating that heterogeneity was established (p<.05*). D. Differences in stress enzymes As for the difference in the stress enzyme α-amylase, no significant difference was found between the two groups in the pretest, so homogeneity was found to be established (p>.05), and a significant difference was found in the posttest, indicating heterogeneity was established (p<.001***). Therefore, the consumption of milk thistle during aerobic exercise in men with fatty liver disease has been shown to be effective in improving liver function and stress enzymes by reducing it. Healthy lifestyle guidelines for the treatment and prevention of liver disease in men with a relatively high risk of liver disease. It is believed that it can be used as basic data.