발광성 실리콘 나노입자 약물전달체

Abstract

Chapter 1. Porous Silicon Nanoparticles as a Drug Delivery System

Today, Silicon nanoparticles with biocompatibility and biodegradability are promising candidates for drug DDS (Drug Delivery System). Porous silicon nanoparticles embedded in a PHEMA (polyhydrohexylmethacrylate) hydrogel matrix are prepared and used to measure the efficiency for controlled release drug delivery. Levofloxacin is a quinolone antibiotic medication and covalently bonded to a surface of porous silicon nanoparticles by condensation. The size of these particles is about a few decades nanometer. Since Levofloxacin has unique optical properties such as an electronic absorption and fluorescence, the release of levofloxacin has measured by fluorescence spectrometer. PL intensity analysis reveals that the porous silicon nanoparticles embedded in a hydrogel polymer matrix exhibit a great potential candidate for controlled release. The controlled drug-release profiles depend on the hydrolysis of Levofloxacin from the surface of porous silicon nanoparticles.

Chapter 2. One-pot Synthesis of Water-Soluble SiliconQuantum Dots

Silicon quantum dots (Si QDs) are promising candidate nano-materials for biological applications due to biocompatibility and biodegradability. Also, Si QDs have unique optical properties. New water-soluble silicon quantum dots (Si QDs) with photoluminescence (PL) in the visible region are simply prepared in one-pot synthesis at room temperature for biomedical applications. Methoxy-derivatized Si QDs, Hydroxide-derivatized Si QDs, Ethylene glycol-derivatized Si QDs, HEA-derivatized Si QDs are water-soluble and their PL characteristics were investigated by PL spectroscopy. The water-soluble Methoxy-derivatized Si QDs, Hydroxide-derivatized Si QDs, Ethylene glycol-derivatized Si QDs, HEA-derivatized Si QDs emit the PL at 420 nm, 408nm, with a full-width at half maximum height (FWHM) of 90 nm, 84nm, 95nm, 83nm in Methanol soultion. Absolute quantum yields were measured in Methanol soultion and were 8.4%, 6.1%, 10.4%, 5%. The integrated PL as a function of time for all water-soluble Si QDs indicates that the PL of water-soluble Si QDs are oxidized in a week. As a result, silicon quantum dots hope to contribute to biological applications.