CHOSUN

Resveratrol induces the apoptosis associated with activation of caspases in HTB-41 human salivary gland epidermoid carcinoma cells

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Author(s)
Kyong Sup Yim Su Gwan Kim Byung Sun Park Dae San Go Chun Sung Kim Do Kyung Kim
Issued Date
2016
Keyword
Cancer therapy Apoptosis Resveratrol Cell death Cancer cells
Abstract
Trans-3,4`,5,-trihydroxystilbene (resveratrol), a phytoalexin that is present in grape skin and red wine, suppresses many types of cancers by regulating cell proliferation and apoptosis through a variety of mechanisms. However, resveratrol`s effects on salivary gland tumors including squamous carcinomas are not clearly established. The main goal of this study was to investigate the effect of resveratrol on cell growth and induction of apoptosis in salivary gland epidermoid carcinoma cells. Treatment with resveratrol induced inhibition of cell growth and was dependent on resveratrol treatment time and concentration in HTB-41 cells. Treatment with resveratrol induced nuclear condensation and fragmentation in HTB-41 cells. Activation of caspases-3 and -7 was detected in living HTB-41 cells by fluorescence microscopy. Resveratrol promoted proteolytic cleavage of procaspases-3, -7, -8 and -9 with increases in the amount of cleaved caspases- 3, -7, -8 and -9. Cleaved PARP increased consider in the presence of resveratrol in HTB-41 cells. These results suggest that resveratrol can induce the suppression of cell growth and cell apoptosis in HTB-41 human submaxillary salivary gland epidermoid carcinoma cells, and that it may have potential properties for anti-cancer drug development.
Publisher
조선대학교 치의학연구원(구 구강생물학연구소)
Citation
Kyong Sup Yim. (2016). Resveratrol induces the apoptosis associated with activation of caspases in HTB-41 human salivary gland epidermoid carcinoma cells, Oral Biology Research (OBR) | Vol.40, No.1 p.16 ~ p.23
Type
Laboratory article
ISSN
2508-2558
URI
https://oak.chosun.ac.kr/handle/2020.oak/17493
http://journal.kstudy.com/ISS_Detail.asp?key=3425432&tname=kiss2002&code=YqldZWtoSqVtJTNENnAtMSUmN/B Z xLJTNEVHJpZQ==
Appears in Collections:
2016 > Vol.40, No.1
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