풀루란을 포함한 상호침투가교 하이드로겔의 합성 및 특성

Abstract

Hydrogels contain hydrophilic functional groups that can absorb water and are highly biocompatible because they are similar to structurally hydrated extracellular matrix. However, when the hydrogel swells, the distance between the polymer chains increases and the mechanical strength decreases. Recently, it has been reported that hydrogels synthesized by interpenetrating polymer network(IPN) with polysaccharides have higher mechanical strength than general hydrogels. In this study, the primary network of the hydrogel was copolymerized with 2-hydroxyethyl methacrylate and vinylpyrrolidone in different ratios, and the secondary network was prepared by IPN-hydrogels with various contents of pullulan, a type of polysaccharide. The characteristics of hydrogels such as water content, tensile strength, morphology, and contact angle were investigated. As a result, it was confirmed that the IPN hydrogel containing pullulan can be used as a high-strength hydrogel material.