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Protein Phosphatase 1D (PPM1D) Structure Prediction Using Homology Modeling

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Author(s)
Santhosh Kumar Nagarajan Thirumurthy Madhavan
Issued Date
2016
Keyword
PPM1D WIP1 PP2C Homology Modelling
Abstract
Protein phosphatase manganese dependent 1D (PPM1D) is one of the Ser/Thr protein phosphatases belongs to the PP2C family. They play an important role in cancer tumorigenesis of various tumors including neuroblastoma, pancreatic adenocarcinoma, medulloblastoma, breast cancer, prostate cancer and ovarian cancer. Even though PPM1D is involved in the pathophysiology of various tumors, the three dimensional protein structure is still unknown. Hence in the present study, homology modelling of PPM1D was performed. 20 different models were modelled using single- and multiple-template based homology modelling and validated using different techniques. Best models were selected based on the validation. Three models were selected and found to have similar structures. The predicted models may be useful as a tool in studying the pathophysiological role of PPM1D
Publisher
조선대학교 기초과학연구원
Citation
Santhosh Kumar Nagarajan. (2016). Protein Phosphatase 1D (PPM1D) Structure Prediction Using Homology Modeling, 조선자연과학논문집 | Vol.9, No.1 p.35 ~ p.40
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/17302
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=list&categoryId=266501&categoryDepth=0010
Appears in Collections:
2016 > Vol.9, No.1
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