한국인 암 생존자의 신체표현형 및 관련 요인

Abstract

Backgrounds

The number of cancer survivors has dramatically increased with advances in early cancer detection and treatment. With the increasing number of cancer survivors, long-term health care has become a critical issue. Recent interest has focused on studying the body size phenotypes with different clinical characteristics and outcomes. This study aimed to explore the body size phenotype of cancer survivors in a nationally representative large general population.

Methods

This study used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional, nationally representative survey conducted by the Korean Ministry of Health and Welfare from 2013 to 2018. A total of 1,472 cancer survivors (547 men and 925 women) were enrolled in this study. Multivariate logistic regression analyses were conducted separately to evaluate the associated risk factors for metabolically abnormal body size phenotypes in groups stratified by sex.

Results

In male cancer survivors, the prevalence rates of metabolically healthy and normal weight (MHNW), metabolically abnormal but normal weight (MANW), metabolically healthy but obese (MHO), and metabolically abnormal obese (MAO) were 53.9%, 13.3%, 12.5%, and 20.3%, respectively. In female cancer survivors, the prevalence rates of MHNW, MANW, MHO, and MAO were 59.3%, 10.3%, 15.7%, and 14.7%, respectively. Mid-high level family income was significantly associated with a higher risk of MANW phenotype regardless of sex (men, odds ratio [OR]: 3.72, 95% confidence interval [CI]: 1.20–11.57; women, OR: 2.89, 95% CI: 1.16–7.21). Aging, fat intake, and middle age at cancer diagnosis were significant risk factors for the MANW phenotype in women. Longer cancer survival time was negatively associated with the risk of MANW phenotype in men. Lower family income and comorbidity were significantly associated with a higher risk of MAO phenotype in women.

Conclusion

Identifying cancer survivors at risk of developing unfavorable body size phenotypes and implementing precise strategies for improvement would be helpful for promoting the survivors’ long-term well-being and the public health.