생체친화적 친수성 소재가 적용된 기능성 하이드로겔 콘택트렌즈의 개발

Abstract

In order to increase the protein non-adsorption and surface wettability of hydrogel contact lenses, poly(ethylene glycol) (PEG) chains were introduced into the lens surface. The PEG-coated lenses showed superior surface wettability than the general HEMA-based contact lenses. It was confirmed that the PEG-applied lens reduced the adsorption of lysozyme and albumin compared to the non-PEG lens. In addition, lenses were manufactured by applying hydrophilic zwitterionic materials, and the physical properties and non-adsorption of bacteria were analyzed. The surfaces of HEMA-A and HEMA-B were coated with zwitterionic materials MPC and DMAPS, resulted in the significant reduction of protein and bacteria adsorption. The lens modification methods studied in this paper improves the wearability by increasing the surface wettability and non-adsorption of proteins and bacteria to the HEMA-based contact lenses, and is evaluated as a method that is fairly easy to apply to lenses. Therefore, it is expected that it can be applied not only to the development of functional hydrogel contact lenses, but also to related medical devices.