천연물 유래 복합 추출물의 퇴행성 골관절염에 대한 항염효과

Abstract

As the average life expectancy increases year by year, the proportion of the elderly population is increasing. According to this, the number of patients with bone diseases such as rheumatoid arthritis and osteoporosis is rapidly increasing as well. Thus, recently there has been a growing interest in the treatment of bone diseases. When we choose the herbal treatment methods of bone diseases, it is not only important to find an effective treatment without side effects used on the patients with bone diseases, but also it needs to increase the therapeutic effect. Recently it has been investigated that herbal medicines can be used as an alternative to avoid side effects of western medicines for bone diseases. In this paper, we reviewed not only the social background, treatments types and the most frequently prescribed herbal medicines, but also the most frequently used individual medicinal herbs as ingredients for the prescribed herbal medicine for bone diseases such as rheumatoid arthritis and osteoporosis. The seven most commonly used herbal medicines for bone diseases investigated in this study are Sasinhwan, Gamiwoogwieum, Woogwieum, Palmijihwanghwan, Yukmijiwhanghwan, Gobongeonyangdan, and Jeopgolsan. In addition, among the individual components of these seven herbal medicines, the eight most regularly used individual medicinal herbs are Rehmanniae Radix Preparata, Dioscoreae Rhizoma, Lycii Fructus, Eucommiae Cortex, Aconiti Lateralis Radix Prepapata, Cinnamomi Cortex, Poria Sclerotium, and Corni Fructus. Also recent studies have shown that these eight medicinal herbs can be individually used to treat bone diseases. Therefore, it is expected that our results in this study can be usefully applied to propose new herbal prescriptions by using these eight medicinal herbs for treatment of bone diseases. After the previous investigational study for osteoarthritis male sprague-Dawley rats were randomized and classified into three different concentration groups to investigate the anti-inflammatory effect on degenerative osteoarthritis. We measured weekly weight change, dietary intake, drinking water intake, blood analysis like TNF-α (tumor necrosis factor-α), IL-6 (interleukin 6), TIMP-1 (tissue inhibitor of metalloprotease-1), MMP-2 (matrix metalloprotease-2), MMP-9 (matrix metalloprotease-9) and micro CT analysis. The results suggest that the treatment with herbal complex HP-04 improved the monosodium iodoacetate (MIA) induced degenerative osteoarthritis and it could be applicable for the improvement of arthritic symptoms as a new herbal medicine.