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Molecular Docking Analysis of Protein Phosphatase 1D (PPM1D) Receptor with SL-175, SL-176 and CDC5L

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Author(s)
Thirumurthy Madhavan
Issued Date
2018
Keyword
PPM1D CDC5L SL-175 SL-176 Molecular Docking Protein-Protein Docking
Abstract
Protein phosphatase manganese dependent 1D (PPM1D), a Ser/Thr protein phosphatise, play major role in the cancer tumorigenesis of various tumors including neuroblastoma, pancreatic adenocarcinoma, medulloblastoma, breast cancer, prostate cancer and ovarian cancer. Hence, analysis on the structural features required for the formation of PPM1Dinhibitor complex becomes essential. In this study, we have performed molecular docking of SL-175 and -176 and proteinprotein docking of CDC5L with PPM1D. On analysing the docked complexes, we have identified the important residues involved in the formation of protein-ligand complex. Research concentrating on these residues could be helpful in understanding the pathophysiology of various tumors related to PPM1D
Publisher
조선대학교 기초과학연구원
Citation
Thirumurthy Madhavan. (2018). Molecular Docking Analysis of Protein Phosphatase 1D (PPM1D) Receptor with SL-175, SL-176 and CDC5L, 조선자연과학논문집 | Vol.11, No.1 p.25 ~ p.29
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/16459
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=view&boardSeq=261300&categoryId=266504&categoryDepth=00120001
Appears in Collections:
2018 > Vol.11, No.1
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