Silver Diamine Fluoride(SDF)의 초기 법랑질 우식에 대한 시간경과에 따른 재광화 효과

Abstract

The purpose of this study was to compare the remineralization effect of Silver Diamine Fluoride (SDF) on demineralized enamel over time with those of fluoride varnish. The specimens were prepared from the extracted bovine teeth with no fractures and sound enamel surface. Artificial early enamel caries were formed by using demineralization solution and divided into 3 groups of 75 each; Group 1(control): artificial saliva, Group 2: MI Varnish™ (5% NaF), Group 3: Advantage Arrest™ (38% SDF). They were stored in artificial saliva for remineralization for 1 day, 3 days, 7 days, 14 days, and 21 days. Then, remineralization effect was compared using Micro-CT, scanning electron microscope (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). The changes in volume and mineral density at the remineralization sites were significantly higher in the MI Varnish™ treated group than in the control group. The changes in volume and mineral density at the remineralization sites in the Advantage Arrest™ treated group were significantly higher than in the control and MI Varnish™ treated groups. The longer the remineralization time in artificial saliva was, the more the remineralization degree increased. The increase rate of remineralization degree was significantly higher in the Advantage Arrest™ treated group. The remineralization rate was high until the first 3 days and gradually decreased thereafter. According to SEM analysis, the surface roughness decreased in the order of Group 1: Control group, Group 2: MI Varnish™ and Group 3: Advantage Arrest™. In addition, Energy-Dispersive X-ray Spectroscopy(EDS) analysis showed that Ag+ ion was contained in the enamel surface of the Advantage Arrest™ group. SDF is a simple, rapid and safe way to prevent new caries and to stop existing caries progression. These results suggest that SDF is useful for patients with young age and systemic diseases who have difficulty in dental treatment.