한국 폐경후 여성에서 근감소성 비만의 유병률과 위험요인 분석

Abstract

Introduction

Sarcopenic obesitycarries the cumulative risk of functional abnormality, metabolic, cardiovascular risk, and mortality compared to either sarcopenia or obesity alone. Sarcopenic obesity is a complex condition interplaying hormonal, biological, nutrition, and physical activity mechanisms. Postmenopauseis related to an increase in visceral adiposity and is associated with the risk of sarcopenic obesity. The objective of the present study was to identify the prevalence of sarcopenic obesity and associated risk factors in Korean in postmenopausal women.

Research Design and Methods

This study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES), conducted by the Korean Ministry of Health and Welfare, from 2009 to 2010. This cross-sectional and nationally representative survey of non-institutionalized civilians used a stratified, multistage, clustered probability sampling design. Out of 19,491 participants, the analysis included data for 2,196 postmenopausal women. Multivariate logistic regression analyses were used to determine an independent associated risk factors with sarcopenic obesity in postmenopausal women.

Results

The prevalence rates of nonsarcopenicnonobesity, nonsarcopenic obesity, sarcopenicnonobesity, and sarcopenic obesity were 48.6%, 16.1%, 15.0%, and 20.3%, respectively. Sarcopenic obesity prevalence differed significantly between the subgroups and increased with earlier age at first childbirth, with 11.7% in subjects ≥ 30 years at first childbirth and 30.7% in subjects ≤ 19 years at first childbirth. Age at first childbirth≤ 19 years(OR 1.719 [95% confidence interval (CI) 1.091–2.711]), known hypertension (OR 1.976 [1.478–2.642]), known arthritis (OR 1.941 [1.529–2.465]), diastolic blood pressure (OR 1.027 [1.008–1.046]), vitamin D level (OR 0.962 [0.942–0.982]), and history of hormone replacement therapy(OR 0.596 [0.406-0.875])were significant associated factors with sarcopenic obesity.

Conclusions

Women’s age at first childbirth and chronic disease influenced the sarcopenic obesity risk in postmenopausal women. The postmenopausal women ≤ 19 years at first childbirthwas independently associated with a higher risk of sarcopenic obesity. The vitamin D level and hormone replacement therapy were significantly associated with reduction of sarcopenic obesity risk.