폐경 여성에서 골다공증 관련인자와 실제 골강도와의 연관성

Abstract

Osteoporosis is known to be a major cause of fracture in postmenopausal women. For the diagnosis of osteoporosis, measurement of bone mineral density (BMD) using Dual energy X-ray Absorptiometry (DXA) is often used along with Fracture Risk Assessment Tool (FRAX®) which was developed to predict the risk of fracture. However, there are number of limitation to these commonly used diagnostic tools; DXA can only measure the density of the bone while the quality of the bone also need to be considered to reflect bone strength. Also, FRAX® uses clinical risk factors to assess to fracture risk and there are debates on whether these tools truly reflect the bone strength. Thus, in this study, we aim to assess the correlation of bone mechanical property as compared to the indirect measurement we commonly used. To fulfil our purpose, we retrieved a femoral head from the patient who developed osteoporotic femoral neck fracture. Mechanical property of femoral head was tested. Statistical analysis was performed to analyze its correlation to the BMD, FRAX® and bone markers.