가토의 두개골 결손부에서 2종 골이식재의 골재생 효과 연구

Abstract

Guide bone regeneration(GBR) has been applied to promote new bone formation for alveolar bone reconstruction at sites with bone defects after tooth loss. Bone graft materials used in GBR can be categorized into autogenous bone, human allograft bone, xenogeneous bone, and synthetic bone depending on the origin. The purpose of this study to compare to bone regeneration effect according to the rate of two different graft bone in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. The 8mm cranial defects were used. Four defects were created in each surgical site. The control group was filled with nothing, group I was filled with 50% xenograft (intergraft. Cellumed Co. Ltd.. Korea) and 50% human FDBA(Regenoss, Cellumed Co. Ltd. Korea) depending on the volume rate, group II was filled with human FDBA only, group III was filled with xenograft only. After healing periods of 4 weeks and 8weeks, histological and histomorphometric analysis were carried out to assess the amount of new bone formation, residual bone graft and connective tissue. At 4weeks, the percent of new bone formation was 18.3% in control group, 6.5% in group I, 8.8% in group II, and 4.2% in group III. The percent of residual bone was 35.9% in group I, 46.6% in group I, and 40.1% in group III, The percent of connective tissue was 81.7% in control group, 57.7% in group I, 44.7% in group II, and 62.41% in group III. At 8weeks, the percent of new bone formation was 14.9% in control group, 36.7% in group I, 39.2% in group II, and 16.8% in group III. The percent of residual bone was 40.5% in group I, 36.5% in group II, 43.7% in group III, The percent of connective tissue was 85.1% in control group, 38.6% in group I, 24.4% in group II, and 48.2% in group III. The results of this study suggest that the higher the proportion of humanFDBA in GBR, the greater the amount of new bone, which is clinically useful. And it was confirmed that a sufficient period of healing should be given in the case of GBR with bone grafting