도파유도체를 갖는 생체모방고분자의 합성 및 특성

Abstract

L-3,4-dihydroxyphenylalanine(DOPA), the critical element that make mussel adhesive proteins is widely known for having strong adhesion strength underwater. Catechol group of DOPA acts as an key structure for adhesion with all kinds of surfaces because of various interactions.[1, 2] In this study, We describe a chemical approach to improve adhesion properties by applying modified DOPA. Also, copolymers with DOPA derivatives and various acrylic monomers were made by free radical polymerization. All products of reaction were characterized by various analytical methods, such as nuclear magnetic resonance(1H-NMR), infrafed spectroscopy(FT-IR), gel permeation chromatography(GPC), therogravimetric analysis(TGA) and differential scanning calorimetry(DSC). Considering these results, one can conclude that copolymers have been synthesized successfully. Moreover, blends of copolymers, pluronic® F127 and divalent cations() were carried out through solution blending to induce the formation of complex coacervate. Adhesion and surface property of polymer blends were measured by LUMIFrac® adhesion analyzer and contact angle analyzer. The result is that adhesive strengths of copolymers and blends were 0.9340 MPa for PDS, 1.0356 MPa for #2 and 0.9340 MPa for #6 (#2 and #6 were composed of Pluronic® F127 or divalent cations). Also, the contact angle of blends were measured less than 90 degrees, which indicated hydrophilicity. The SEM micrographs of cross-section surface did not have a substantial effect on the blends morphology such as shape or phase separation.