도파유도체를 갖는 생체모방고분자의 합성 및 특성

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L-3,4-dihydroxyphenylalanine(DOPA), the critical element that make mussel adhesive proteins is widely known for having strong adhesion strength underwater.
Catechol group of DOPA acts as an key structure for adhesion with all kinds of surfaces because of various interactions.[1, 2]
In this study, We describe a chemical approach to improve adhesion properties by applying modified DOPA. Also, copolymers with DOPA derivatives and various acrylic monomers were made by free radical polymerization. All products of reaction were characterized by various analytical methods, such as nuclear magnetic resonance(1H-NMR), infrafed spectroscopy(FT-IR), gel permeation chromatography(GPC), therogravimetric analysis(TGA) and differential scanning calorimetry(DSC). Considering these results, one can conclude that copolymers have been synthesized successfully. Moreover, blends of copolymers, pluronic® F127 and divalent cations() were carried out through solution blending to induce the formation of complex coacervate. Adhesion and surface property of polymer blends were measured by LUMIFrac® adhesion analyzer and contact angle analyzer. The result is that adhesive strengths of copolymers and blends were 0.9340 MPa for PDS, 1.0356 MPa for #2 and 0.9340 MPa for #6 (#2 and #6 were composed of Pluronic® F127 or divalent cations). Also, the contact angle of blends were measured less than 90 degrees, which indicated hydrophilicity. The SEM micrographs of cross-section surface did not have a substantial effect on the blends morphology such as shape or phase separation.
Alternative Title
Syntheses and Characterization of Biomimetic Polymers Based on DOPA Derivatives
Alternative Author(s)
Cho, Na Rae
조선대학교 일반대학원
일반대학원 첨단소재공학과
최재곤, 손정선
Awarded Date
Table Of Contents
제 1 장 서론 1
1. 1. 의료용 접착제 1
1. 2. L-3,4-dihydroxyphenylalnine (DOPA) 4
1. 3. 본 연구의 목적 7
제 2 장 실험 8
2. 1. 시약 및 기기 8
2. 1. 1. 시약 8
2. 1. 2. 기기 8
2. 2. 단위체의 합성 9
2. 3. 공중합체의 합성 13
2. 3. 1. Poly(DMA-co-MEA)의 합성 13
2. 3. 2. Poly(DMA-co-MEA-co-ECA)의 합성 17
2. 3. 3. Poly(DMA-co-HEMA)의 합성 21
2. 3. 4. Poly(DMA-co-SBMA)의 합성 25
제 3 장 결과 및 고찰 29
3. 1. 공중합체의 일반적 성질 29
3. 2. 공중합체의 블렌드 제조 30
3. 3. 공중합체의 열적 특성 32
3. 4. 공중합체 및 블렌드의 접착 특성 35
3. 5. 공중합체 및 블렌드의 모폴로지 47
제 4 장 결론 50
참고 문헌 51
조선대학교 일반대학원
조나래. (2016). 도파유도체를 갖는 생체모방고분자의 합성 및 특성.
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General Graduate School > 3. Theses(Master)
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