대상포진 환자의 말초혈액 내 Th17세포와 Treg세포의 변화에 관한 연구

Abstract

Background: Although the mechanisms involved in reactivation of latent varicella-zoster virus (VZV) are unclear, immunosuppression and age-related deficiency of cell-mediated immunity are important factors involved in reactivation. CD4+CD25+Foxp3+ regulatory T cells (Treg) and T-hepler 17 cells (Th17) are closed associated with a various viral infections. Currently, the association between Th17 and Treg cells and herpes zoster are unknown. Objective: In this study, the Treg and Th17 cells proportion in peripheral blood were evaluated between patients with herpes zoster and healthy controls. And we compared the changes of Treg and Th17 cell before and after treatment. Methods: Proportions of Treg and Th17 cells in peripheral blood were examined in herpes zoster patients and healthy controls. The changes of Treg and Th17 cells between pre-treatment and post-treatment and clinical parameters in herpes zoster patients were also analyzed. Results: There was significant decrease in circulating Treg cells proportion in herpes zoster patients compared to control (p=0.003). The ratio of Th17 to Treg cells was significant increased compare to control (p=0.021). In contrast to the Treg cells, there was no significant difference in Th17 cells proportion in herpes zoster patients compared to control(p=0.157). There was no significant difference in Treg, Th17 cells and ratio of Th17 to Treg cells between pre-treatment and post-treatment (p=0.149, p=0.236, p=0.725) and between non-postherpetic neuralgia (non-PHN) group and PHN group (p=0.444, p=0.591, p=0.448). And the changes of Treg, Th17 cells and the ratio of Th17 to Treg cells was no significant correlation with changes of VAS (p=0.158, p=0.494, p=0.420). Conclusion: These findings provide that there is an imbalance in Th17 and Treg cells associated with reactivation of VZV, which may contribute to pathogenesis of herpes zoster.