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대상포진 환자의 말초혈액 내 Th17세포와 Treg세포의 변화에 관한 연구

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Author(s)
김동진
Issued Date
2016
Keyword
Herpes zoster, Treg cells, Th17 cells
Abstract
Background: Although the mechanisms involved in reactivation of latent varicella-zoster virus (VZV) are unclear, immunosuppression and age-related deficiency of cell-mediated immunity are important factors involved in reactivation. CD4+CD25+Foxp3+ regulatory T cells (Treg) and T-hepler 17 cells (Th17) are closed associated with a various viral infections. Currently, the association between Th17 and Treg cells and herpes zoster are unknown.
Objective: In this study, the Treg and Th17 cells proportion in peripheral blood were evaluated between patients with herpes zoster and healthy controls. And we compared the changes of Treg and Th17 cell before and after treatment.
Methods: Proportions of Treg and Th17 cells in peripheral blood were examined in herpes zoster patients and healthy controls. The changes of Treg and Th17 cells between pre-treatment and post-treatment and clinical parameters in herpes zoster patients were also analyzed.
Results: There was significant decrease in circulating Treg cells proportion in herpes zoster patients compared to control (p=0.003). The ratio of Th17 to Treg cells was significant increased compare to control (p=0.021). In contrast to the Treg cells, there was no significant difference in Th17 cells proportion in herpes zoster patients compared to control(p=0.157). There was no significant difference in Treg, Th17 cells and ratio of Th17 to Treg cells between pre-treatment and post-treatment (p=0.149, p=0.236, p=0.725) and between non-postherpetic neuralgia (non-PHN) group and PHN group (p=0.444, p=0.591, p=0.448). And the changes of Treg, Th17 cells and the ratio of Th17 to Treg cells was no significant correlation with changes of VAS (p=0.158, p=0.494, p=0.420).
Conclusion: These findings provide that there is an imbalance in Th17 and Treg cells associated with reactivation of VZV, which may contribute to pathogenesis of herpes zoster.
Alternative Title
A Study of the Changes of Th17 cells and Regulatory T cells in Herpes zoster
Alternative Author(s)
Kim, Dong Jin
Department
일반대학원 의학과
Advisor
신봉석
Awarded Date
2016-08
Table Of Contents
Ⅰ. 서론 1
Ⅱ. 대상 및 방법 3
1. 연구대상 3
2. 연구방법 3
1) 세포분리 3
2) 유세포분석 4
3) 통계학적분석 5
Ⅲ. 결과 6
Ⅳ. 고찰 8
Ⅴ. 결론 12

【참고문헌】 13
Degree
Master
Publisher
조선대학교
Citation
김동진. (2016). 대상포진 환자의 말초혈액 내 Th17세포와 Treg세포의 변화에 관한 연구.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/12894
http://chosun.dcollection.net/common/orgView/200000265666
Appears in Collections:
General Graduate School > 3. Theses(Master)
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