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다제내성 Acinetobacter baumannii 균주에 대한 Colistin, Tigecycline, Doripenem의 병합요법

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Author(s)
박균철
Issued Date
2015
Abstract
The objective of this study is to evaluate the in vitro synergistic activity of colistin, tigecycline, and doripenem combinations against Multidrug-resistant (MDR) Acinetobacter baumannii. A total of 109 A. baumannii isolates including 60 non-XDR, 49 XDR strains were used in this study. In time kill assays, colistin plus doripenem, and colistin plus tigecycline combinations showed bactericidal synergy in ten (20.4%) and six (12.2%) isolates against XDR strains and eight (13.3%) and eighteen (30%) isolates against non-XDR strains, respectively. Antagonism was detected with the all antibiotic combinations, varied from 13.3~38.8%. These findings may add useful information to plan successful combination therapies for infections caused by XDR and non-XDR A.baumannii.
Alternative Title
Colistin, Tigecycline and Doripenem Combinations Against Multidrug-Resistant Acinetobacter baumannii
Alternative Author(s)
Park Gyun Cheol
Affiliation
조선대학교 진단검사의학과
Department
일반대학원 의학과
Advisor
장숙진
Awarded Date
2015-08
Table Of Contents
Ⅰ. 서론·················································································1


Ⅱ. 연구 및 대상방법····························································2
A. 대상··················································2
B. 항생제 감수성 검사································2
C. 시간-살균 검사·····································3
D. 통계 분석···········································3

Ⅲ. 결과·················································································4
A. 항생제 감수성 검사 결과···························4
B. 시간-살균 검사 결과·································4

Ⅳ. 고찰·················································································7

【참고문헌】·········································································10
Degree
Master
Publisher
조선대학교
Citation
박균철. (2015). 다제내성 Acinetobacter baumannii 균주에 대한 Colistin, Tigecycline, Doripenem의 병합요법.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/12500
http://chosun.dcollection.net/common/orgView/200000265002
Appears in Collections:
General Graduate School > 3. Theses(Master)
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  • Embargo2015-08-25
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