다제내성 Acinetobacter baumannii 균주에 대한 Colistin, Tigecycline, Doripenem의 병합요법

Abstract

The objective of this study is to evaluate the in vitro synergistic activity of colistin, tigecycline, and doripenem combinations against Multidrug-resistant (MDR) Acinetobacter baumannii. A total of 109 A. baumannii isolates including 60 non-XDR, 49 XDR strains were used in this study. In time kill assays, colistin plus doripenem, and colistin plus tigecycline combinations showed bactericidal synergy in ten (20.4%) and six (12.2%) isolates against XDR strains and eight (13.3%) and eighteen (30%) isolates against non-XDR strains, respectively. Antagonism was detected with the all antibiotic combinations, varied from 13.3~38.8%. These findings may add useful information to plan successful combination therapies for infections caused by XDR and non-XDR A.baumannii.