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항 바이러스제로서 새로운 5′-데옥시뉴클레오사이드 포스폰산의 합성

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Author(s)
김경미
Issued Date
2014
Abstract
Novel Fluorinated phosphonic acid analogues were designed and synthesized to mimic naturally occurring purine monophosphate from commercially available 1,3-dihydroxyacetone. The discovery of threosyl phosphonate nucleoside (PMDTA, EC50 = 2.53 μM) as a potent anti-HIV agent has led to the synthesis and biological evaluation of 2',3'-modified 5'-deoxyversions of the threosyl phosphonate nucleosides. The synthesized 2´-fluoro-3´-hydroxymethyl 5´-deoxythreosyl phosphonic acid nucleoside analogues 14, 18, 23, and 27 were tested for anti-HIV activity as well as cytotoxicity. The adenine analogue 18 exhibits weak in vitro anti-HIV-1 activity (EC50 = 19.2 μM)
Alternative Title
Synthesis of Novel 5′-Deoxynucleoside Phosphonic Acid as Antiviral Agents
Alternative Author(s)
Kim, Kyung Mi
Department
일반대학원 약학과
Advisor
홍준희
Awarded Date
2014-08
Table Of Contents
약 어
ABSTRACT
Ⅰ. 연구 배경 ………………………………………………………………… 1
Ⅱ. 서 론 ……………………………………………………………………… 3
Ⅲ. 결과 및 고찰 ……………………………………………………………… 5
Ⅳ. 결 론……………………………………………………………………… 11
Ⅴ. 실험 방법 ………………………………………………………………… 12
참고문헌 ……………………………………………………………………… 27
국문초록 ……………………………………………………………………… 33
Degree
Master
Publisher
조선대학교 대학원
Citation
김경미. (2014). 항 바이러스제로서 새로운 5′-데옥시뉴클레오사이드 포스폰산의 합성.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/12337
http://chosun.dcollection.net/common/orgView/200000276419
Appears in Collections:
General Graduate School > 3. Theses(Master)
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