급성 두드러기를 주소로 내원한 소아의 혈청 총 IgE 수치와 알레르겐 특이항체 검사에 대한 연구

Abstract

ABSTRACT Study of total IgE lever and allergen specific IgE in children with acute urticaria

Cho So Yeo Advisor : Prof. Yang Eun Seok M.D., Ph.D. Department of Medicine, Graduate School of Chosun University

Objectives: Increased total IgE and eosinophil count levels are frequently observed in cutaneous inflammation and are thought to provoke the occurrence of urticaria. This study is aimed to measure serum total IgE levels, specific IgE sensitization rates and blood eosinophil count and investigate the relationship between those factors to evaluate the significance of allergy blood tests in children with acute urticaria.

Methods: Among the children who visited the Department of Pediatrics at Chosun University Hospital from January 2011 to December 2013, we retroprospectively analyzed 63 patients with acute urticaria. Positive rates of the total serum IgE level, specific IgE and blood eosinophil count were analyzed in patients with acute urticaria.

Results: 63 patients were included in the study and the rate of males to female was 1: 0.8. Mean age was 6.41±4.97 years(range 0-17years). Among the subjects, 42.9% of patients showed an elevated serum total IgE and 63.5% of patients revealed at least more than one allergen-specific IgE by MAST-CLA. The mean number of allergens that were detected in the positive patients was 2.42±2.56/patient. As for aeroallergens(outdoor and indoor), Birch Alder Mix, Oak. white, Rye, and Derm. farinae showed the high positivity rate in that order. Meanwhile, as for food allergens, Milk, Chedar Cheese, Egg white, and Beef showed the high positivity rate in that order. The serum total IgE and the allergen specific IgE were significantly positively correlated (OR = 0.290, p=0.02). However, no significant correlation was found between the peripheral eosinophil count and the serum total IgE, and between the peripheral eosinophil count and the allergen specific IgE.

Conclusion: This study is meaningful as it revealed a positive correlation between serum total IgE and allergen specific IgE in the urticaria patients. If a further study is prospectively conducted on pediatric patients on a large scale, it could be possible to predict allergen specific IgE positively with a certain level of serum total IgE. In addition, a more significant result is expected to be obtained for the correlation among peripheral eosinophil count, serum total IgE, and allergen specific IgE.

Key words : Allergen-specific IgE, Total IgE, Blood eosinophil. MAST-CLA, Urticaria.