티타니아 나노 입자를 이용한 치과용 임플란트 픽스처 표면처리

Abstract

The physicochemical feature of implant surface is an important factor for a successful implant osseointegration. The researches related to this have been conducted to shorten healing period and to obtain a stable adhesion between implant surface and jawbone after implant placement. However, although the making methods of oxide film is various for implant surface is various, research for dental implant fixture is rarely conducted. Recently, the research using nanostructured titania (titanium dioxide, TiO2) has attracted the attention owing to the wide scope and excellence of nanoscale metal oxide semiconductor and photocatalytic reaction. Also, several researches show that structure of nano-titania has made nano scale-bony structure affected to osteoblast adhesion, proliferation and morphological kidney, and differentiation of mesenchymal stem cells into osteoblasts. The purpose of this study was to provide experimental basic data to increase utilization and availability of the material for implant fixture surface modification. Titania oxide sol containing nanoparticles was prepared and titania thin film on implant surface made by sol-gel method and analyzed its physicochemical characteristics. Finally, the cell viablility by MTT assay wass performed to elutes from TiO2-treated implant fixture. Main purpose of this study is to evaluate the availaility of oxide nanoparticles titania as functional materials for surface modification and besides, to confirm whether or not sol-gel method is useful to titania coating technology. As a result, 10 implants of diameter 4.3mm, length 10mm were coated with a thin film on dental implant fixture using titania nanoparticles. The optimal mixture ratio of Titanium butoxide and Isoproply Alcohol was 5, 95 %, respectively and the optimal dipping time for sample coating was 4 times. Surface analysis showed that Ti and O composition detected in all experimental groups treated with titania nanoparticles and consequently, this data present that surface coated with titania and coating on surface was treated uniformly. Ti content of thin film showed highly in all experimental groups than the control expect for 25 degree-treated sample. The result of surface roughness analysis showed that surface roughness uniformly formed in 2 time coated-all groups. 97% of titanium butoxide treatedd relatively uniform the thin film on fixture surface. The elute from titania treated-fixtures did not affect cell viability. In conclusion, the fixture treated with titania particles is non-toxic and effective surface appearance, and it showed an excellent effect on the initial bone formation after the implant. On the basis of this study, it is expected new surface treatment material of dental implant fixture, using titania and nano-technology, with more active research, would be developed. Also surface treatment by anodic oxidation technique, to compliment the weakness of sol-gel process, is expected to be complementary in order to increase the uniformity of the coated titania particles on the surface of the fixture and to enhance the adhesion of titania particles.