NSAID의 물리화학적 특성이 경피흡수에 미치는 영향
- Issued Date
- 2013
- Abstract
- Propanoic acid derivatives: ibuprofen, ketoprofen, naproxen, flurbiprofen, dexibuprofen and loxoprofen were selected as model drugs for the study. Physicochemical properties of the drugs including the molecular weight, the lipid/water partition coefficient, melting point and aqueous solubility were correlated with the flux values. Properties of the compounds had a profound effect on the release from the transdermal patch and subsequent penetration into the skin. The most reliable parameter was found to be the melting point of drug as best correlation was found between the fluxes of drugs having similar melting points
- Alternative Title
- The effect of physicochemical properties of NSAID on the transdermal drug delivery
- Alternative Author(s)
- Hwansig Moon
- Affiliation
- 조선대학교 대학원 식품의약학과
- Department
- 일반대학원 식품의약학과
- Advisor
- 최후균
- Awarded Date
- 2014-02
- Table Of Contents
- 목 차
국문 초록 ------------------------------------------------------------------vi
Abstract --------------------------------------------------------------------vii
제1장 피부를 통한 약물흡수 예측 연구 동향
1. 서론------------------------------------------------------------------------1
2. 경피흡수제제--------------------------------------------------------------3
2.1. 구성성분-----------------------------------------------------------------3
2.1.1. 약물--------------------------------------------------------------------3
2.1.2. 점착제------------------------------------------------------------------3
2.1.3. 흡수촉진제-------------------------------------------------------------7
2.1.4. 결정 생성 억제제----------------------------------------------------12
2.2. 경피흡수 제형----------------------------------------------------------14
3. 피부를 통한 약물 흡수 예측에 대한 연구 동향-----------------------17
4. 결론-----------------------------------------------------------------------22
5. 참고문헌------------------------------------------------------------------23
제2장 NSAID의 물리화학적 특성이 경피흡수에 미치는 영향 연구
1. 서론-----------------------------------------------------------------------29
2. 시약 및 실험방법--------------------------------------------------------33
2.1. 시약--------------------------------------------------------------------33
2.2. 실험방법----------------------------------------------------------------33
2.2.1. 약물을 포함하는 adhesive matrix의 제조-------------------------33
2.2.2. In vitro 경피투과 실험-----------------------------------------------34
2.2.3. 분석방법--------------------------------------------------------------35
3. 결과 및 고찰-------------------------------------------------------------36
3.1. aryl group의 영향-----------------------------------------------------36
3.2. 광학이성질체-----------------------------------------------------------36
3.3. Log P-------------------------------------------------------------------37
3.4. 분자량------------------------------------------------------------------38
3.5. 용해도------------------------------------------------------------------39
3.6. 녹는점------------------------------------------------------------------39
4. 결론-----------------------------------------------------------------------41
5. 참고문헌------------------------------------------------------------------42
- Degree
- Doctor
- Publisher
- 조선대학교 대학원
- Citation
- 문환식. (2013). NSAID의 물리화학적 특성이 경피흡수에 미치는 영향.
- Type
- Dissertation
- URI
- https://oak.chosun.ac.kr/handle/2020.oak/11867
http://chosun.dcollection.net/common/orgView/200000264163
- Appears in Collections:
- General Graduate School > 4. Theses(Ph.D)
- Files in This Item:
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