과민성방광증후군 환자에서 성별에 따른 증상 정도와 스트레스 및 우울과의 관련성

Abstract

ABSTRACT

Association of Overactive Bladder Syndrome with Stress and Depression; Differences by Gender

Nam, Ji-Young Advisor : Prof. Choi, Seong-Woo M.D., Ph.D Department of Public Health Graduate School of Health Science, Chosun University

Objective: Several studies have reported a correlation between overactive bladder syndrome (OAB) and stress and depression. However, there is little data on the relationship between OAB and stress. The purpose of this study is to determine whether OAB is related to stress and depression, and to identify gender differences.

Methods: The study enrolled 200 patients diagnosed with OAB. The severity of OAB symptoms was estimated by the OAB Symptom Scale (OABSS). For epidemiological studies, the Perceived Stress Scale (PSS) and Center-Depression Scale (CESD) were used to estimate stress levels and depression. Registered patients were divided into several groups according to gender and OABSS. Mild symptoms were defined as OABSS ≤ 5, moderate witnesses 6 ≤ OABSS ≤ 11, and severe syndrome OABSS ≥ 12. Data was analyzed using descriptive analysis, correlation, multiple regression and Analysis of covariance (ANCOVA) analysis using the SPSS version 22.0 statistical program.

Results: PSS according to OABSS were mild (p=0.013) and moderate (p<0.001) significantly higher in females than in males. There was no significant difference in severity (p=0.168). ANCOVA analysis after adjusting for age, BMI, spouse, and sleeping time with meaningful difference between males and females. In the moderate symptom group, there was a significant difference 11.2(0.8) in males and 15.7(0.9) in females (p<0.001). There was no significant difference between mild and severe. CES-D according to OABSS were moderate (P<0.001) significantly higher in females than in males. There was no significant difference in mild (p=0.125) and severe (p=0.958). ANCOVA analysis after adjusting for age, spouse, and sleeping time with meaningful difference between males and females. In the moderate symptom group, there was a significant difference 7.2(0.9) in males and 12.3(1.1) in females (p=0.001). In the trend test the OAB severity and PSS, after modified the variables with significant differences, tended to increase in males (p for trend=0.039) and females (p for trend=0.059), but there was no significant correlation in CES-D.

Conclusion: Symptoms of OAB can affect stress and depression for both males and females. In particular, females with moderate OAB had higher levels of stress (p<0.001) and depression (p=0.001) than males. As the OABSS severity increased, both males (p for trend=0.048) and females (p fer trend=0.059) showed tendency to increase PSS.

Keyword: overactive bladder, stress, depression, gender