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소태나무 껍질의 항암효과에 대한 연구

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Author(s)
김유숙
Issued Date
2009
Abstract
ABSTRACT
Anti-proliferative effects of the Picrasma quassioides Benn bark extract in the human oral carcinoma cells(KB cells)

Kim, Yu-Suk.
Advisor:
Prof. Park Sang-Hag M.D., Ph.D.
Department of Alternative Medicine,
Graduate School of Health Science
Chosun University

Picrasma quassioides Benn. blossoms in June, olive color, and it is a dioecism. The component of PQB, quassin, is a bittering agent and it stimulates appetite as a stomachics. The water extract of the component of PQB had highest anti-oxidative effect and the methanol extract and 70% ethanol extract followed. The methanol extract had highest inhibitory activity of α-Glucosidase and the water extract followed.
To find out the anti-cancer effect of the component of PQB for oral cavity carcinoma I checked the cell survival rate using in the human oral carcinoma cells(KB cell). When I checked the KB cell survival rate using hot-water extract and methanol extract, there was no differences in hot-water extract but meaningful differences in low-concentration(10, 20, 30, 40, 50㎍/㎖) of methanol extract by concentration-dependent manner. In addition, when I analyzed protein bands which I got in protein isolation by electrophoresis, it didn't affect the expression of β-actin while it inhibited the production of COX-2 by concentration-dependent manner.
For these results, it could be strongly suggested that the methanol extract of PQB is very effective for prevention and treatment of the oral cavity carcinoma
Alternative Title
Anti-proliferative effects of the Picrasma quassioides Benn bark extract in the human oral carcinoma cells(KB cells)
Alternative Author(s)
Kim, Yu Suk
Affiliation
조선대학교 보건대학원 대체의학과
Department
보건대학원 대체의학과
Advisor
박상학
Awarded Date
2010. 2
Table Of Contents
목 차

LIST OF FIGURES ⅱ
ABSTRACT iii
Ⅰ. 서론 1
Ⅱ. 실험 재료 및 방법
1. 실험 재료
1) 재료 3
2) 시약 3
2. 방법
1) KB세포 배양 3
2) MTS assay 3
3) western blot 3
3. 통계처리 4
Ⅲ. 실험결과
1. 세포 생존률에 미치는 영향
1) 열수 추출 5
2) 메탄올 추출 7
2 Western blot 10
Ⅳ. 고찰 11
Ⅴ. 결론 14
References
Degree
Master
Publisher
조선대학교
Citation
김유숙. (2009). 소태나무 껍질의 항암효과에 대한 연구
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/2167
http://chosun.dcollection.net/common/orgView/200000239402
Appears in Collections:
Medicine & Parmacy > Theses(Master)(의학전문대학원/보건대학원/임상약학대학원)
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