마전자(Strychnos nux-vomica) 추출물이 구강암 세포주(KB cell) 증식억제에 미치는 영향

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김 동 순
Issued Date
Oral cancer or oral cavity cancer, a subtype of head and neck cancer, is any cancerous tissue growth located in the oral cavity. Chemotherapy is useful in oral cancers when used in combination with other treatment modalities such as radiation therapy. It is seldom used alone as a monotherapy. The properties of Strychnos nux-vomica are substantially those of the alkaloid strychnine. The powdered seeds are employed in atonic dyspepsia. The tincture of Strychnos nux-vomica is often used in mixtures. But, extract of Strychnos nox-vomica is known as toxin because of its containments, brucine, the toxical alkaloids. Many recent studies and reports show that its toxical agent may cause the effects on the cancer therapy. First, extracts of Strychnos nux-vomica were collected by is often usedand methanol extract methods. Then treated with KB cells to while its cell growth and conformed that extract actually suppressed the cell growths. Therefore, this paper indicate that the major alkaloids present in the Strychnos nux-vomica are effective against KB cells growth.
Alternative Title
Anti-proliferating effect of Strychnos nux-vomica extracts on KB oral carcinoma cell lines
Alternative Author(s)
Kim, Dong Soon
조선대학교 보건대학원 대체의학과
보건대학원 대체의학과
문 경래교수님
Awarded Date
2010. 2
Table Of Contents
목 차
그림목차 ⅱ

Ⅰ.서론 1

Ⅱ.실험 재료 및 방법 3
1. 실험 재료 3
(1) 마전자의 수집 및 추출 3
(2) 시약 3
2. 추출방법 3
(1) 열수 추출 3
(2) 메탄올 추출 4
3. 분석방법 4
(1) 구강암 세포주 KB 배양과 화학적 처리 4
(2) MTS assay 4
(3) Western blot analysis 5
4. 통계처리 5

Ⅲ. 실험결과 6
1. 세포 생존율 미치는 영향 6
(1) 열수 추출 6
(2) 메탄올 추출 8
2. western blotting 10

Ⅳ. 고찰 11

V. 결론 13

참고문헌 14
김 동 순. (2009). 마전자(Strychnos nux-vomica) 추출물이 구강암 세포주(KB cell) 증식억제에 미치는 영향
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Medicine & Parmacy > Theses(Master)(의학전문대학원/보건대학원/임상약학대학원)
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