https://oak.chosun.ac.kr/handle/2020.oak/18664 Thu, 28 Aug 2025 15:16:12 GMT 2025-08-28T15:16:12Z https://oak.chosun.ac.kr/handle/2020.oak/18677 Title: Phytochemical Screening and Biological Studies of Boerhavia Diffusa Linn Author(s): Prakriti Gautam; Sandesh Panthi; Prashubha Bhandari; Jihoon Shin; Jin Cheol Yoo Abstract: Hexane, ethyl acetate and methanol extracts of whole plant of Boerhavia diffusa were screened for phytochemical and biological activities. Qualitative phytochemical screening via colorimetric method and the quantitative estimation of phenolic and flavonoid content were performed. Antioxidant assay using DPPH scavenging method was studied. Antimicrobial screening of plant extracts was done by cup diffusion technique. Cytotoxic activity of B. diffusa was studied by brine shrimp bioassay and anthelminthic activity was evaluated in vitro in Pheretima posthuma. This study revealed B. diffusa as a source of various phyto-constituents such as alkaloids, glycosides, saponins, tannins, carbohydrates, cardiac glycosides, flavonoids and terpenoids. Quantitative estimation of total phenol was found to be maximum in BEE i.e. $29.73{\pm}0.88$ 수식 이미지, BME $19.8{\pm}2.02$ 수식 이미지 and in BHE $9.15{\pm}0.304mgGAE/g$ 수식 이미지. Similarly, the total flavonoid content was found to be $17.44{\pm}0.75$ 수식 이미지 in BEE, $14.43{\pm}0.23$ 수식 이미지 in BHE and 3.678 mg QE/g in BME. Ethyl acetate extract showed its antibacterial activity against all tested pathogens except Escherichia coli whereas Staphylococcus aureus and Salmonella Typhi were resistant to methanol and hexane extract. The zone of inhibition (ZOI) of ethyl acetate extract against S. Typhi and B. cereus was found to be 18 mm and 14 mm respectively. The MIC value of BEE in S. Typhi was $3.125{\mu}g/ml$ 수식 이미지 and in B. cereus was $12.5{\mu}g/ml$ 수식 이미지. The preliminary screening of anticancer property of B. diffusa i.e. BSLT in methanol was found to be $165.19{\mu}g/ml$ 수식 이미지. B. diffusa was also found to contain anthelmintic property. The study helped in further exploration of medicinal properties of B. diffusa by phytochemical screening and biological activities paving the path for study and investigation in this plant. Thu, 31 Dec 2015 15:00:00 GMT https://oak.chosun.ac.kr/handle/2020.oak/18677 2015-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18676 Title: Mathematical Approach on Composition of Nomination Committee for University President Election Author(s): Sucheol Yi; Sunyeong Heo Abstract: The university president direct election system in Korea had begun in 1987 as a movement of college democratization in the 1980s after 6.29 Declaration. Since then, many national/private universities had adopted the election system. However, it has posed many problems and it caused a sharp division of opinions between those who approve and disapprove the direct election system. Since 2005, the government has made official of the reformation and/or abolition of the university president direct election system, and has kept pushing for universities to give up the direct election system. Now, only 3 or 4 universities hold on to the system, and many universities have changed into the indirect election system. In the indirect election, a key is the composition of president nomination committee, which confirms the university members's variety. Many universities adopting the indirect election system have used simple random sampling, like drawing lots, to compose the president nomination committee. However, drawing lots has a problem that it has large possibility of composing a biased committee. This research suggests systematic sampling as an alternative to drawing lots. A numerical analysis was conducted using a data of a university in which the indirect election was implemented recently. The drawing lots gave the biased nomination committee. On the other hand, the systematic sample improves the problem and confirms more the variety of all members. Thu, 31 Dec 2015 15:00:00 GMT https://oak.chosun.ac.kr/handle/2020.oak/18676 2015-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18674 Title: Pharmacophore Based Screening and Molecular Docking Study of PI3K Inhibitors Author(s): Mottadi Rupa; Thirumurthy Madhavan Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Phosphoinositide 3-kinases (PI3Ks) play important role in Non-Small Cell Lung Cancer. PI3Ks constitute a lipid kinase family which modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth. Herein, we describe the ligand based pharmacophore combined with molecular docking studies methods to identify new potent PI3K inhibitors. Several pharmacophore models were generated and validated by Guner-Henry scoring Method. The best models were utilized as 3D pharmacophore query to screen against ZINC database (Chemical and Natural) and the retrieved hits were further validated by fitness score, Lipinski's rule of five. Finally four compounds were found to have good potential and they may act as novel lead compounds for PI3K inhibitor designing Thu, 31 Dec 2015 15:00:00 GMT https://oak.chosun.ac.kr/handle/2020.oak/18674 2015-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18675 Title: Spectroscopic and Mechanical Properties of Nano Silica Rubber Composite Material Author(s): Jung Kyu Lee; Juyun Park; Yong-Cheol Kang; Sung Wi Koh Abstract: To manipulate the mechanical properties of acrylonitrile butadiene rubber (NBR), addition of nano-sized silica on rubber was performed and nano-silica NBR composite (NSR) materials were fabricated by press molding. The effect of volume fraction of silica in the NSR on the spectroscopic and mechanical properties has been studied Thu, 31 Dec 2015 15:00:00 GMT https://oak.chosun.ac.kr/handle/2020.oak/18675 2015-12-31T15:00:00Z