https://oak.chosun.ac.kr/handle/2020.oak/18711 2026-04-09T19:07:12Z https://oak.chosun.ac.kr/handle/2020.oak/18735 Title: Hologram Quantitative Structure-Activity Relationships Study of N-Phenyl-N’-{4-(4-quinolyloxy)phenyl} Urea Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors Author(s): Seketoulie Keretsu; Pavithra K. Balasubramanian; Swapnil P. Bhujbal; Seung Joo Cho Abstract: Vascular endothelial growth factor (VEGF) is an important signaling protein involved in angiogenesis, which is the formation of new blood vessels from pre-existing vessels. Consequently, blocking of the vascular endothelial growth factor receptor (VEGFR-2) by small molecule inhibitors leads to the inhibition of cancer induced angiogenesis. In this study, we performed a two dimensional quantitative structure activity relationship (2D-QSAR) study of 38 N-Phenyl-N'-{4-(4-quinolyloxy) phenyl} urea derivatives as VEGFR-2 inhibitors based on hologram quantitative structure-activity (HQSAR). The model developed showed reasonable $q^2=0.521$ 수식 이미지 and $r^2=0.932$ 수식 이미지 values indicating good predictive ability and reliability. The atomic contribution map analysis of most active compound (compound 7) indicates that hydrogen and oxygen atoms in the side chain of ring A and oxygen atom in side chain of ring C contributes positively to the activity of the compounds. The HQSAR model developed and the atomic contribution map can serve as a guideline in designing new compounds for VEGFR-2 inhibition. 2016-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18737 Title: Antimicrobial and Antioxidant Peptide from Bacillus Strain CBS73 Isolated from Korean Food Author(s): Miri Kim; Md Maruf Khan; Jin Cheol Yoo Abstract: An antimicrobial peptides-producing Bacillus strain CBS73 was isolated from fermented food (kimchi) that produces low-molecular-weight proteins with broad-spectrum antimicrobial activity. Our goal was to explore the therapeutic potential of antimicrobial substances produced by Bacillus species. Peptide CBS73 was purified from Bacillus subtilis subsp. subtilis with identity of 99.79%. It was found to be stable at pH 4.0-10.0 and temp $20-60^{\circ}C$ 수식 이미지. A protein band around 5.2 kDa was detected in tricine-SDS-PAGE and band was confirmed by MALDI-TOF test. Peptide CBS73 showed antimicrobial activity against MDR bacteria. The minimal inhibitory concentration (MIC) of peptide CBS73 for vancomycin-resistant S. aureus (VRSA), vancomycin resistant Enterococci (VRE) and Salmonella typhimurium ranged from $10-40{\mu}g/mL$ 수식 이미지. The antioxidant activity of peptide CBS73 was measured by DPPH scavenging, reducing power activity and total phenolic content. Cell viability and NO production result showed less cytotoxic effect upto $12{\mu}g/mL$ 수식 이미지. Peptide CBS73 could be a promising antimicrobial agent for clinical application. 2016-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18738 Title: Design of Case-based Intelligent Wheelchair Monitoring System Author(s): Tae Yeun Kim; Dae Woong Seo; Sang Hyun Bae Abstract: In this paper, it is aim to implement a wheelchair monitoring system that provides users with customized medical services easily in everyday life, together with mobility guarantee, which is the most basic requirement of the elderly and disabled persons with physical disabilities. The case-based intelligent wheelchair monitoring system proposed in this study is based on a case-based k-NN algorithm, which implements a system for constructing and inferring examples of various biometric and environmental information of wheelchair users as a knowledge database and a monitoring interface for wheelchair users. In order to confirm the usefulness of the case-based k-NN algorithm, the SVM algorithm showed an average accuracy of 84.2% and the average accuracy of the proposed case-based k-NN algorithm was 86.2% And showed higher performance in terms of accuracy. The system implemented in this paper has the advantage of measuring biometric information and data communication regardless of time and place and it can provide customized service of wheelchair user through user friendly interface. 2016-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/18733 Title: 13C NMR-Study of 1,1-Dipotassio-2,3,4,5-Tetraphenyl-1-Silacyclopentadienide Dianion [SiC4Ph4]2−•2[K+] and 1,1-Dipotassio-2,3,4,5-Tetraphenyl-1-Germacyclopentadienide Dianion [GeC4Ph4]2−•2[K+] Author(s): Jang-Hwan Hong Abstract: The chemical shifts in the 13C NMR spectra of 2,3,4,5-tetraphenyl-1-silacyclopentdienide dianion [SiC4Ph4]2−•2[K+] (3) and 2,3,4,5-tetraphenyl-1-germacyclopentdienide dianion [GeC4Ph4]2−•2[K+] (4) were compared to those of [SiC4Ph4]2−•2[Li+] (5), [SiC4Ph4]2−•2[Na+] (6), and [GeC4Ph4]2−•2[Li+] (7). The average polarizations in two phenyl groups of two potassium salts are decreased over 15% to 20% comparing to those of the lithium salts and sodium salt {[EC4Ph4]2−•2[M+] (E=Si, Ge, M=Li, Na) due to the effect of the counter potassium cation 2016-12-31T15:00:00Z