https://oak.chosun.ac.kr/handle/2020.oak/18286 2025-08-28T13:38:42Z https://oak.chosun.ac.kr/handle/2020.oak/19109 Title: Inhibitory effect of pomegranate extract powder on periodontitis in rat Author(s): Joong-hwa Kim; Kyung-hyun Lee; Se-jin Sung; Kyung-min Kang; Yun-kyong Lim; Joong-ki Kook; Won-pyo Lee; Byung-ock Kim; Sang-joun Yu Abstract: This study aimed to investigate the effect of pomegranate extract (PE) on the progression of periodontal disease in an experimental rat model of periodontitis. Periodontitis was induced in rats by placing a 5-0 black silk ligature and injecting a lipopolysaccharide of Porphyromonas gingivalis into the gingiva. Distilled water (DW) or PE solution was orally administered daily, and the animals were sacrificed after 3 weeks. Tissue specimens of the periodontitis model were analyzed using an enzyme-linked immunosorbent assay kit and by micro-computed tomography (CT) imaging. The expression levels of cyclo-oxygenase (COX)-1 and COX-2 were significantly reduced in ligation (Lig)+PE 22 μg/mL and Lig+PE 44 μg/mL groups, but there was no statistically significant difference in matrix metalloproteinase (MMP)-8 levels. Furthermore, micro-CT imaging demonstrated that alveolar bone resorption was inhibited in Lig+PE 22 μg/mL and Lig+PE 44 μg/mL groups compared with that in the Lig+DW group. These results demonstrate that PE has an inhibitory effect on the progression of alveolar bone loss caused by periodontal inflammation by reducing the expression levels of COX-1 and COX-2 in the process of periodontal disease. 2019-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/19110 Title: Comparison of changes in the buccal keratinized mucosa between the minimally-invasive crestal incision and apically-positioned full-thickness flap methods for stage-two implant surgery Author(s): Keon-il Yang; Jun-mo Yang; Ki-won Lee; Won-pyo Lee; Byung-ock Kim; Sang-joun Yu Abstract: Stage-two implant surgery, which exposes the implant platform to connect the healing abutment, affects the width of the peri-implant keratinized mucosa thereby affecting the long-term prognosis of the implant. The purpose of this study was to compare the changes in the width of the peri-implant buccal keratinized mucosa between the minimally-invasive crestal incision (MCI) procedure and the apically-positioned full-thickness flap (APFTF) method during stage-two implant surgery. A total of 74 implants were placed in 41 patients. The MCI group included 27 implant cases wherein, healing abutments were connected after stage-two implant surgery using the MCI in 18 patients. The APFTF group comprised 47 implant cases wherein, healing abutments were connected after stage-two implant surgery using the APFTF method in 23 patients. The buccal keratinized mucosa widths (BKMW) of the healing abutment and prosthesis were measured at the mesial, central, and distal aspects after the stage-two surgery and the final restoration. A decrease in the BKMW in both groups after stage-two implant surgery was observed when compared with those after the final restoration; furthermore, the BKMW was significantly lower after stage-two implant surgery in the MCI group (p <0.001). No statistically significant difference in BKMW was noted between the MCI and APFTF groups at any point. These results reveal that the APFTF method was more effective than MCI in terms of preserving the buccal peri-implant keratinized mucosa during stage-two implant surgery. 2019-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/19111 Title: A rare case of chronic nonbacterial osteomyelitis of the mandible in a young adult male Author(s): Yesel Kim; Jinhyuk Choi; Hoi-in Jung; Jeong-kui Ku Abstract: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a rare disease of unknown etiology mainly affecting girls with a mean age of 10 years. The disease is characterized by nonbacterial osteolytic lesions and swelling of the adjacent soft tissues and has nonstandard treatment protocols. Unifocal CNO typically involves the mandible. Mandibular CNO is difficult to differentiate from bacterial osteomyelitis because of its similar radiographic profile and clinical symptoms. Therefore, magnetic resonance imaging (MRI) should be considered if infectious osteomyelitis has not been diagnosed by laboratory examination. Our patient was a young adult man with mandibular CNO presented with atypical bone fragments on MRI. Clinical symptoms improved within 3 days after surgical intervention to remove the fragments and treatment with a nonsteroidal anti-inflammatory drug (NSAID). NSAID therapy was discontinued at postoperative day 20, and the patient has experienced no recurrences at 5 months after surgery. 2019-12-31T15:00:00Z https://oak.chosun.ac.kr/handle/2020.oak/19107 Title: Interrelation between plasma membrane calcium ATPase-1 and inflammatory mediators expression in gingival tissue depending on severity of periodontitis Author(s): Da-le Yoon; Su-yeon Park; Yong-gun Kim; Jae-mok Lee Abstract: We investigated the effects of severity of periodontitis on inflammation progression by observing the expression and interaction of inflammatory mediators such as plasma membrane calcium ATPase (PMCA)-1, interleukin (IL)-11, and leukemia inhibitory factor (LIF), which are involved in bone metabolism, in healthy tissues and tissues according to the severity of inflammation. The aim of this study was to investigate the effect of these factors on periodontal tissue destruction. Gingival tissue specimens were collected from patients with periodontal disease and healthy individuals, at the Department of Periodontics, Kyungpook National University Dental Hospital. Specimen was recruited from the patients were obtained during periodontal surgery. Western blotting was used to observe the expression of PMCA-1, IL-11, and LIF in each tissue. The expression of PMCA-1 was increased in periodontitis groups and was highest in severe periodontitis group. IL-11 expression was increased in periodontitis groups and was highest in severe periodontitis group. LIF expression was decreased in periodontitis groups and was highest in normal group. There were a statistically significant difference between normal and moderate group, normal and severe periodontitis group, and moderate and severe periodontitis group. In conclusion, PMCA-1, IL-11, and LIF appear to be associated with the severity of chronic periodontitis. These factors may influence each other 2019-12-31T15:00:00Z