https://oak.chosun.ac.kr/handle/2020.oak/18710 2026-04-09T17:44:04Z 2026-04-09T17:44:04Z Pavithra K. Balasubramanian Anand Balupuri Seung Joo Cho https://oak.chosun.ac.kr/handle/2020.oak/18727 2024-04-26T06:04:39Z 2016-12-31T15:00:00Z

Title: 3D-QSAR Study on Imidazopyridazines Derivatives as Potent Pim-1 Kinase Inhibitors using Region-Focused CoMFA Author(s): Pavithra K. Balasubramanian; Anand Balupuri; Seung Joo Cho Abstract: Proviral Integration site of Moloney (Pim) murine Leukemia virus kinases is a serine/threonine specific protein kinase. It is largely involved in cell survival and proliferation. Pim-1 phosphorylates multiple cellular substrates to inhibit apoptosis and promote cell cycle progression. Over expression of Pim-1 kinase is observed in a range of malignancies and various solid cancers. High level of Pim-1 expression is seen in myeloma, acute myeloid leukemia, prostate cancer and liver carcinomas. Hence, Pim-1 is considered as an interesting cancer target. In the present study, we have performed region-focused CoMFA study on a series of imidazopyridazine derivatives as Pim-1 kinase inhibitors. A statistically acceptable region-focused CoMFA model ($q^2=0.571$ 수식 이미지; ONC=3; $r^2=0.909$ 수식 이미지) was developed. The model was then validated using Bootsrapping and progressive sampling. The contour map highlighted the regions favorable to increase the activity. Bulky substitutions in $R^2$ 수식 이미지 position of the phenyl ring could increase the activity. Similarly, small negative substitution in the $R^1$ 수식 이미지 position of the Pyridine ring could increase the activity considerably. Our results will be useful to design novel Pim-1 kinase inhibitors of this series.

2016-12-31T15:00:00Z Sathya. B https://oak.chosun.ac.kr/handle/2020.oak/18728 2024-04-26T06:04:39Z 2016-12-31T15:00:00Z

Title: Molecular Docking Study of Urotension-2 Receptor (UTS2R) Author(s): Sathya. B Abstract: Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. Hence, we have performed molecular docking of six antagonists with different inhibitory activity against UTS2R into its binding site. The binding mode of these antagonists was obtained using Surflex dock program interfaced in Sybyl-X2.0. The residues such as GLN278, THR304, TYR305, THR300, LEU299, CYS302, ASP47, TYR100 and THR304 are found in interaction between UTS2R and its antagonists. This study could be useful for identifying and analyzing the important residues involved in binding site of UTS2R receptor.

2016-12-31T15:00:00Z Ka Kyung Ahn https://oak.chosun.ac.kr/handle/2020.oak/18730 2024-04-26T06:04:39Z 2016-12-31T15:00:00Z

Title: A-Frequent Hypercyclicity in an Algebra of Operators Author(s): Ka Kyung Ahn Abstract: We study a notion of $\mathcal{A}$ 수식 이미지-frequent hypercyclicity of linear maps between the Banach algebras consisting of operators on a separable infinite dimensional Banach space. We prove a sufficient condition for a linear map to satisfy the $\mathcal{A}$ 수식 이미지-frequent hypercyclicity in the strong operator topology.

2016-12-31T15:00:00Z Won Sok Yoo https://oak.chosun.ac.kr/handle/2020.oak/18729 2024-04-26T06:04:39Z 2016-12-31T15:00:00Z

Title: The Geometry Descriptions of Crystallographic Groups of Sol Author(s): Won Sok Yoo Abstract: The connected and simply connected four-dimensional matrix solvable Lie group $Sol^4_1$ 수식 이미지 is the four-dimensional geometry. A crystallographic group of $Sol^4_1$ 수식 이미지 is a discrete cocompact subgroup of $Sol^4_1{\rtimes}D(4)$ 수식 이미지. In this paper, we geometrically describe the crystallographic groups of $Sol^4_1$ 수식 이미지.

2016-12-31T15:00:00Z