https://oak.chosun.ac.kr/handle/2020.oak/18667 2026-04-09T15:09:35Z 2026-04-09T15:09:35Z Duck-Hyun Kim A-Young Sung https://oak.chosun.ac.kr/handle/2020.oak/18702 2024-04-26T05:54:19Z 2015-12-31T15:00:00Z

Title: Protein Absorption and Characterization of Hydrogel Polymer Containing 2-Methacryloyloxyethyl Phosphorylcholine as Additive Author(s): Duck-Hyun Kim; A-Young Sung Abstract: This study evaluated the physical and optical characteristics of hydrophilic ophthalmic polymer with addition of 2-methacryloyloxyethyl phosphorylcholine in the basic hydrogel ophthalmic lens material, and in particular, the utility of 2-methacryloyloxyethyl phosphorylcholine as an ophthalmic contact lens material for ophthalmologic devices was investigated. In this study 2-methacryloyloxyethyl phosphorylcholine were used as additives. For the preparation of hydrogel lens 2-hydroxyethyl methacrylate, methyl methacrylate, acrylic acid and a cross-linker EGDMA were copolymerized in the presence of AIBN as an initiator. The physical properties of the produced polymers were measured as followings. The refractive index of 1.433~1.393, water content of 35.95~53.16%, contact angle of $70.6{\sim}51.24^{\circ}$ 수식 이미지, UVB transmittance of 81.2~82.4%, UV-B transmittance of 81.2~82.4% and visible transmittance of 91.4~92.2% were obtained. Also, in case of protein absorption, the measurement showed that absorbance of Reference and MPC-10 sample was 0.2598 and 0.2250 respectively. Based on the results of this study, ophthalmic lens material containing 2-methacryloyloxyethyl phosphorylcholine is expected to be used usefully as a material for high wettability and inhibitor of protein adsorption for ophthalmic hydrogel lens.

2015-12-31T15:00:00Z Santhosh Kumar Nagarajan Thirumurthy Madhavan https://oak.chosun.ac.kr/handle/2020.oak/18700 2024-04-26T05:54:19Z 2015-12-31T15:00:00Z

Title: Theoretical Structure Prediction of Bradykinin Receptor B2 Using Comparative Modeling Author(s): Santhosh Kumar Nagarajan; Thirumurthy Madhavan Abstract: Bradykinin receptor B2, a GPCR protein, binds with the inflammatory mediator hormone bradkynin. It plays an important role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). Also, it is involved in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Hence, studuying the structural features of the receptor becomes important. But the unavailability of the three dimensional structure of the protein makes the analysis difficult. Hence we have performed the homology modelling of Bradykinin receptor B2 with 5 different templates. 25 different homology models were constructed. Two best models were selected based on the model validation. The developed models could be helpful in analysing the structural features of Bradykinin receptor B2 and in pathophysiology of various disorders related to them.

2015-12-31T15:00:00Z Dong Su Lee In Hong Chang https://oak.chosun.ac.kr/handle/2020.oak/18707 2024-04-26T05:54:19Z 2015-12-31T15:00:00Z

Title: An Analysis of the Impact of Adolescents’ Impulsivity, Academic Procrastination and School Adaptability Using R Author(s): Dong Su Lee; In Hong Chang Abstract: This study examines the causal relationship between adolescent impulsivity, academic procrastination and school adaptability. The main purpose of this study is to confirm the degree of influence among these variables and analyze the causes of school adaptability. In this model, impulsivity and academic procrastination were set as independent variables and school adaptability was set as a dependent variable. Impulsivity of adolescents affects academic procrastination and school adaptability, and academic procrastination will affect school adaptability. As a result of the research, first, it can be seen that adolescents 'cognition impulsivity, motion impulsivity, and unplanned impulsivity have a significant influence on behavioral in adolescents'. Second, adolescents' cognition impulsivity, motion impulsivity, and unplanned impulsivity a significant influence on the cognitive in the adolescents'. Third, adolescents' behavioral, cognitive, and emotional have a significant influence on school adaptability in adolescents' school adaptability. In conclusion, we proposed a policy proposal on school adaptability by deriving meaning to improve adolescents' school adaptability.

2015-12-31T15:00:00Z P. Malathy G. Jagadeesan K. Gunasekaran S. Aravindhan https://oak.chosun.ac.kr/handle/2020.oak/18705 2024-04-26T05:54:19Z 2015-12-31T15:00:00Z

Title: Molecular Docking Studies of Wolbachia Endosymbiont of Brugia Malayi’s Carbonic Anhydrase Using Coumarin-chromene Derivatives Towards Designing Anti-filarial Agents Author(s): P. Malathy; G. Jagadeesan; K. Gunasekaran; S. Aravindhan Abstract: Filariasis causing nematode Brugia malayi is shown to harbor wolbachia bacteria as symbionts. The sequenced genome of the wolbachia endosymbiont from B.malayi (wBm) offers an unprecedented opportunity to identify new wolbachia drug targets. Hence the enzyme carbonic anhydrase from wolbachia endosymbiont of Brugia malayi (wBm) which is responsible for the reversible interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa) is chosen as the drug target for filariasis. This enzyme is thought to play critical functions in bacteria by involving in various steps of their life cycle which are important for survival, The 3D structure of wBm carbonic anhydrase is predicted by selecting a suitable template using the similarity search tool, BLAST. The BLAST results shows a hexapeptide transferase family protein from Anaplasma phagocytophilum (PDB ID: 3IXC) having 77% similarity and 54% identity with wBm carbonic anhydrase. Hence the above enzyme is chosen as the template and the 3D structure of carbonic anhydrase is predicted by the tool Modeller9v7. Since the three dimensional structure of carbonic anhydrase from wolbachia endosymbiont of Brugia malayi has not yet solved, attempts were made to predict this protein. The predicted structure is validated and also molecular docking studies are carried out with the suitable inhibitors that have been solved experimentally.

2015-12-31T15:00:00Z